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1 papers 0 to 25 followers This TRIAL give us some tools for appraise the use of TNK in patients with pulmonary embolism with intermediate risk to develop major complications. I Just say to You three things: 1. Is better to use TNK, because TNK reduces mortality in 56%, OR: 0,44. P=0,02. With a CI: 95%.// 2. Relative risk reduction is 33%, but Absolute risk reduction was 0,9%. So no even one patient get alive with TNK use; and finally I get pretty worried about NNT, that was 110. So I have to treat 110 patients to save a life with TNK. 3. There were signifficant bad outcomes in TNK patients Who treated with. Major extracranial bleeding and haemorrhagic stroke within 7 days after randomization. Just use It carefully and with a specialist opinion.
Guy Meyer, Eric Vicaut, Thierry Danays, Giancarlo Agnelli, Cecilia Becattini, Jan Beyer-Westendorf, Erich Bluhmki, Helene Bouvaist, Benjamin Brenner, Francis Couturaud, Claudia Dellas, Klaus Empen, Ana Franca, Nazzareno Galiè, Annette Geibel, Samuel Z Goldhaber, David Jimenez, Matija Kozak, Christian Kupatt, Nils Kucher, Irene M Lang, Mareike Lankeit, Nicolas Meneveau, Gerard Pacouret, Massimiliano Palazzini, Antoniu Petris, Piotr Pruszczyk, Matteo Rugolotto, Aldo Salvi, Sebastian Schellong, Mustapha Sebbane, Bozena Sobkowicz, Branislav S Stefanovic, Holger Thiele, Adam Torbicki, Franck Verschuren, Stavros V Konstantinides
BACKGROUND: The role of fibrinolytic therapy in patients with intermediate-risk pulmonary embolism is controversial. METHODS: In a randomized, double-blind trial, we compared tenecteplase plus heparin with placebo plus heparin in normotensive patients with intermediate-risk pulmonary embolism. Eligible patients had right ventricular dysfunction on echocardiography or computed tomography, as well as myocardial injury as indicated by a positive test for cardiac troponin I or troponin T...
April 10, 2014: New England Journal of Medicine
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