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ESTROGEN DOM-PCOS

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4 papers 25 to 100 followers
By Brooke Manor Endocrinology
https://www.readbyqxmd.com/read/23460719/the-role-of-estrogens-in-control-of-energy-balance-and-glucose-homeostasis
#1
REVIEW
Franck Mauvais-Jarvis, Deborah J Clegg, Andrea L Hevener
Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular, skeletal, and central nervous systems. In this report, we review the literature in both rodents and humans on the role of estrogens and their receptors in the control of energy homeostasis and glucose metabolism in health and metabolic diseases. Estrogen actions in hypothalamic nuclei differentially control food intake, energy expenditure, and white adipose tissue distribution. Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity as well as prevention of lipid accumulation and inflammation...
June 2013: Endocrine Reviews
https://www.readbyqxmd.com/read/24694334/associations-between-insulin-resistance-free-fatty-acids-and-oocyte-quality-in-polycystic-ovary-syndrome-during-in-vitro-fertilization
#2
Zhihong Niu, Nan Lin, Ruihuan Gu, Yijuan Sun, Yun Feng
CONTEXT: Both polycystic ovary syndrome (PCOS) and obesity are associated with specific reproductive health complications, including lower oocyte quality and clinical pregnancy rates in assisted conception cycles, which may be a result of metabolism-induced changes in the oocyte through the microenvironment of follicular fluid. Free fatty acids (FFAs) are important biomedical indicators of abnormal lipid metabolism and have pronounced effects on cells, leading to changes in metabolism, cell growth, and differentiation...
November 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24333009/anastrozole-for-prevention-of-breast-cancer-in-high-risk-postmenopausal-women-ibis-ii-an-international-double-blind-randomised-placebo-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Jack Cuzick, Ivana Sestak, John F Forbes, Mitch Dowsett, Jill Knox, Simon Cawthorn, Christobel Saunders, Nicola Roche, Robert E Mansel, Gunter von Minckwitz, Bernardo Bonanni, Tiina Palva, Anthony Howell
BACKGROUND: Aromatase inhibitors effectively prevent breast cancer recurrence and development of new contralateral tumours in postmenopausal women. We assessed the efficacy and safety of the aromatase inhibitor anastrozole for prevention of breast cancer in postmenopausal women who are at high risk of the disease. METHODS: Between Feb 2, 2003, and Jan 31, 2012, we recruited postmenopausal women aged 40-70 years from 18 countries into an international, double-blind, randomised placebo-controlled trial...
March 22, 2014: Lancet
https://www.readbyqxmd.com/read/23065822/insulin-resistance-and-the-polycystic-ovary-syndrome-revisited-an-update-on-mechanisms-and-implications
#4
REVIEW
Evanthia Diamanti-Kandarakis, Andrea Dunaif
Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected women have marked insulin resistance, independent of obesity. This article summarizes the state of the science since we last reviewed the field in the Endocrine Reviews in 1997. There is general agreement that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity. There is a post-binding defect in receptor signaling likely due to increased receptor and insulin receptor substrate-1 serine phosphorylation that selectively affects metabolic but not mitogenic pathways in classic insulin target tissues and in the ovary...
December 2012: Endocrine Reviews
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