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Colorectal cancer

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By Giovanni Gambino M.D. Ph.D.
Takehito Yamamoto, Takeshi Morimoto, Ryosuke Kita, Hideyuki Masui, Hiromitsu Kinoshita, Yusuke Sakamoto, Kazuyuki Okada, Junji Komori, Akira Miki, Masato Kondo, Kenji Uryuhara, Hiroyuki Kobayashi, Hiroki Hashida, Satoshi Kaihara, Ryo Hosotani
BACKGROUND: Incisional surgical site infection (SSI) is one of the most frequent complications that occur after colorectal surgery. Surgery for colorectal perforation carries an especially high risk of incisional SSI because fecal ascites contaminates the incision intraoperatively, and in patients who underwent stoma creation, the incision is located near the infective origin and is subject to infection postoperatively. Although effectiveness of the preventive SSI bundle of elective colorectal surgery has been reported, no study has focused exclusively on emergency surgery for colorectal perforation...
December 18, 2015: BMC Surgery
Hsiang-Lin Tsai, Ching-Wen Huang, Yung-Sung Yeh, Cheng-Jen Ma, Chao-Wen Chen, Chien-Yu Lu, Ming-Yii Huang, I-Ping Yang, Jaw-Yuan Wang
BACKGROUND: To identify factors affecting the harvest of lymph nodes (LNs) and to investigate the association between examining a minimum of 12 LNs and clinical outcomes in stage I-III colorectal cancer (CRC) patients. METHODS: The clinicopathologic features and the number of examined LNs for 1167 stage I-III CRC patients were analyzed to identify factors affecting the number of LNs harvested and the correlations between clinical outcomes and high harvests (≧12 LNs) and low harvests (<12 LNs)...
April 14, 2016: BMC Surgery
Hyun Sung Kim, Sanghwa Ko, Nahm-gun Oh
BACKGROUND: Intersphincteric resection (ISR) has become an increasingly popular optional surgical tool for the treatment of very low rectal cancer. The purpose of this study was to assess the long-term oncological and functional outcomes of intersphincteric resection for T2 and T3 rectal cancer situated below 4 cm from the anal verge. METHODS: A total of 62 consecutive patients with very low rectal cancer who underwent ISR from 2001 to 2010 were classified into standard ISR for T2 lesions (Group I, n = 24) and extended ISR for T3 lesions (Group II, n = 38)...
April 18, 2016: BMC Surgery
Kenneth Smedh, Ingvar Sverrisson, Abbas Chabok, Maziar Nikberg
BACKGROUND: The use of Hartmann's procedure in the old and frail and/or in patients with fecal incontinence is increasing, even though some data have reported high postoperative rates of pelvic abscesses. Abdominoperineal excision with intersphincteric dissection has been proposed as a better alternative and is performed increasingly both nationally and internationally. However, no studies have been performed to support this. The aim of this study is to randomize patients between Hartmann's procedure and abdominoperineal excision with intersphincteric dissection and compare post-operative surgical morbidity and quality of life...
July 11, 2016: BMC Surgery
Alice Charlotte Adelaide Murray, Ravi P Kiran
No abstract text is available yet for this article.
September 2016: Advances in Surgery
Rahila Essani, Roberto Bergamaschi
No abstract text is available yet for this article.
September 2016: Advances in Surgery
A J Breugom, T A Vermeer, C B M van den Broek, T Vuong, E Bastiaannet, L Azoulay, O M Dekkers, T Niazi, H A van den Berg, H J T Rutten, C J H van de Velde
AIM: High-dose-rate brachytherapy (HDRBT) appears to be associated with less treatment-related toxicity compared with external beam radiotherapy in patients with rectal cancer. The present study compared the effect of preoperative treatment strategies on overall survival, cancer-specific deaths, and local recurrences between a Dutch and Canadian expert center with different preoperative treatment strategies. PATIENTS AND METHODS: We included 145 Dutch and 141 Canadian patients with cT3, non-metastasized rectal cancer...
August 2015: European Journal of Surgical Oncology
C Fischer, H F Lingsma, N van Leersum, R A E M Tollenaar, M W Wouters, E W Steyerberg
OBJECTIVE: When comparing performance across hospitals it is essential to consider the noise caused by low hospital case volume and to perform adequate case-mix adjustment. We aimed to quantify the role of noise and case-mix adjustment on standardized postoperative mortality and anastomotic leakage (AL) rates. METHODS: We studied 13,120 patients who underwent colon cancer resection in 85 Dutch hospitals. We addressed differences between hospitals in postoperative mortality and AL, using fixed (ignoring noise) and random effects (incorporating noise) logistic regression models with general and additional, disease specific, case-mix adjustment...
August 2015: European Journal of Surgical Oncology
Takuya Matsumoto, Suguru Hasegawa, Masazumi Zaima, Naoya Inoue, Yoshiharu Sakai
AIM: The efficacy of neoadjuvant chemotherapy without radiation (NAC) in the treatment of rectal cancer remains unclear. This retrospective study was aimed at determining the pathological complete response rate and short-term outcomes of NAC in patients with locally advanced rectal cancer. PATIENTS AND METHODS: We collected data on 159 consecutive patients treated for rectal cancer (cT3/cT4a, cN+, and cM0 status) at five tertiary referral hospitals between 2005 and 2010...
2015: Digestive Surgery
Pieter J Tanis, Nuno R Paulino Pereira, Jeanin E van Hooft, Esther C J Consten, Willem A Bemelman
BACKGROUND/AIMS: The prematurely closed Stent-In II trial in patients with left-sided obstructive colon cancer may have influenced clinical decision making in The Netherlands. The aim of this study was to evaluate treatment of left-sided malignant colon obstruction at a population level since then. METHODS: Short-term outcomes of all patients who underwent resection for left-sided obstructive colon cancer between 2009 and 2012 were assessed based on a prospective national registry...
2015: Digestive Surgery
M J Wilkinson, J E F Fitzgerald, D C Strauss, A J Hayes, J M Thomas, C Messiou, C Fisher, C Benson, P P Tekkis, I Judson
BACKGROUND: Gastrointestinal stromal tumours (GISTs) of the rectum often require radical surgery to achieve complete resection. This study investigated the management and outcome of surgery for rectal GISTs and the role of imatinib. METHODS: A cohort study was undertaken of patients identified from a database at one tertiary sarcoma referral centre over a continuous period, from January 2001 to January 2013. RESULTS: Over 12 years, 19 patients presented with a primary rectal GIST...
July 2015: British Journal of Surgery
Fabio Cianchi, Giacomo Trallori, Beatrice Mallardi, Giuseppe Macrì, Maria Rosa Biagini, Gabriele Lami, Giampiero Indennitate, Siro Bagnoli, Andrea Bonanomi, Luca Messerini, Benedetta Badii, Fabio Staderini, Ileana Skalamera, Giulia Fiorenza, Giuliano Perigli
BACKGROUND: Some recent studies have suggested that laparoscopic surgery for colorectal cancer may provide a potential survival advantage when compared with open surgery. This study aimed to compare cancer-related survivals of patients who underwent laparoscopic or open resection of colon cancer in the same, high volume tertiary center. METHODS: Patients who had undergone elective open or laparoscopic surgery for colon cancer between January 2002 and December 2010 were analyzed...
March 25, 2015: BMC Surgery
Ignazio Tarantino, Rene Warschkow, Ulrich Güller
No abstract text is available yet for this article.
June 15, 2015: Annals of Surgery
John E Scarborough, Christopher R Mantyh, Zhifei Sun, John Migaly
OBJECTIVE: To determine the association between preoperative bowel preparation and 30-day outcomes after elective colorectal resection. METHODS: Patients from the 2012 Colectomy-Targeted American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database who underwent elective colorectal resection were included for analysis and assigned to 1 of 4 groups based on the type of preoperative preparation they received [combined mechanical and oral antibiotic preparation (OAP), mechanical preparation only, OAP only, or no preoperative bowel preparation]...
August 2015: Annals of Surgery
Ahmad Elnahas, David Urbach, Gerald Lebovic, Muhammad Mamdani, Allan Okrainec, Fayez A Quereshy, Timothy D Jackson
BACKGROUND: Routine preoperative mechanical bowel preparation (MBP) for left-sided colorectal resections remains controversial. This study aims to evaluate the association between MBP and 30-day anastomotic leaks. METHODS: A retrospective cohort study was conducted using data from the National Surgical Quality Improvement Program from 2011 to 2012. Multiple imputation was used for missing data, and a multivariable logistic regression was performed to adjust for clinically relevant variables...
November 2015: American Journal of Surgery
Mitsuyoshi Tei, Masaki Wakasugi, Hiroki Akamatsu
BACKGROUND: Single-port surgery is a recent advancement in minimally invasive techniques for colon disease. However, single-port laparoscopic rectal resection (SPLR) is rare. The aim of this study was to compare the short-term results of SPLR with those of multi-port laparoscopic rectal resection (MPLR) for rectal cancer. METHODS: Patients who underwent SPLR (n = 50) or MPLR (n = 50) for rectal cancer from July 2010 to March 2014 were analyzed. Patients with tumor diameter less than 40 mm and body mass index less than 30 kg/m(2) were matched for age, sex, tumor location, and preoperative evaluation...
August 2015: American Journal of Surgery
Nathalie Bakker, Hamit Cakir, H J Doodeman, A P J Houdijk
BACKGROUND: Perioperative treatment of patients with colorectal cancer according to the Enhanced Recovery After Surgery (ERAS) protocol has proven to reduce complications and duration of stay. However, strict adherence remains a challenge and the benefits may decrease with lower adherence. In this study, we report on 8 years of adherence to the ERAS protocol and its effect on postoperative outcome in patients with colon cancer. METHODS: In 2006, the ERAS protocol was introduced for treatment of colon cancer patients in the Medical Center Alkmaar, a large teaching hospital...
June 2015: Surgery
Francesco Di Fabio, Leonid Barkhatov, Italo Bonadio, Eleonora Dimovska, Åsmund A Fretland, Neil W Pearce, Roberto I Troisi, Bjørn Edwin, Mohammed Abu Hilal
BACKGROUND: Laparoscopic liver surgery is expanding. Most laparoscopic liver resections for colorectal carcinoma metastases are performed subsequent to the resection of the colorectal primary, raising concerns about the feasibility and safety of advanced laparoscopic liver surgery in the context of an abdomen with possible postoperative adhesions. The aim was to compare the outcome of laparoscopic hepatectomy for colorectal metastases after open versus laparoscopic colorectal surgery...
June 2015: Surgery
Soo Young Lee, Je-ho Jang, Duck-Woo Kim, Jangho Park, Heung-Kwon Oh, Myong Hoon Ihn, Ho-Seong Han, Jae Hwan Oh, Sang Jae Park, Sung-Bum Kang
BACKGROUND AND AIMS: The feasibility of incidental cholecystectomy during colorectal cancer (CRC) surgery has not been determined as yet. We aimed to investigate the feasibility of incidental cholecystectomy during CRC surgery. METHODS: The clinicopathologic data of patients who underwent CRC surgery between January 2004 and May 2011 were assessed. Patients with asymptomatic cholelithiasis were divided into groups that did and did not undergo incidental cholecystectomy...
2015: Digestive Surgery
A M Wolthuis, S Fieuws, A Van Den Bosch, A de Buck van Overstraeten, A D'Hoore
BACKGROUND: Although conventional laparoscopic colectomy is a validated technique, laparoscopic natural-orifice specimen extraction (NOSE) colectomy might improve outcome. This randomized clinical trial compared analgesia requirements, postoperative pain, anorectal function, inflammatory response and cosmesis in laparoscopic NOSE colectomy and conventional laparoscopic colectomy. METHODS: Patients were randomly assigned to undergo laparoscopic NOSE colectomy or conventional laparoscopic colectomy for left-sided colonic disease...
May 2015: British Journal of Surgery
2015-04-05 19:03:24
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