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selective decontamination saves, chlorhexadine kills? BMJ 2014

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4 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
Humberto C Sasieta, Finbar Foley, Cassandra M Batzlaff
No abstract text is available yet for this article.
May 15, 2015: American Journal of Respiratory and Critical Care Medicine
Cindy L Munro, Mary Jo Grap, Curtis N Sessler, Ronald K Elswick, Devanand Mangar, Rachel Karlnoski-Everall, Paula Cairns
BACKGROUND: Daily application of oral chlorhexidine gluconate (CHX) following intubation to reduce the risk of ventilator-associated pneumonia (VAP) is now the standard of care in many ICUs. This randomized clinical trial evaluated the benefit of adding a preintubation CHX dose to the known benefit of postintubation CHX to reduce the risk of early-onset VAP. A secondary aim was to test the effect of a preintubation oral application of CHX on early endotracheal tube (ETT) colonization...
February 2015: Chest
Evelien A N Oostdijk, Jozef Kesecioglu, Marcus J Schultz, Caroline E Visser, Evert de Jonge, Einar H R van Essen, Alexandra T Bernards, Ilse Purmer, Roland Brimicombe, Dennis Bergmans, Frank van Tiel, Frank H Bosch, Ellen Mascini, Arjanne van Griethuysen, Alexander Bindels, Arjan Jansz, Fred A L van Steveninck, Wil C van der Zwet, Jan Willem Fijen, Steven Thijsen, Remko de Jong, Joke Oudbier, Adrienne Raben, Eric van der Vorm, Mirelle Koeman, Philip Rothbarth, Annemieke Rijkeboer, Paul Gruteke, Helga Hart-Sweet, Paul Peerbooms, Lex J Winsser, Anne-Marie W van Elsacker-Niele, Kees Demmendaal, Afke Brandenburg, Anne Marie G A de Smet, Marc J M Bonten
IMPORTANCE: Selective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) are prophylactic antibiotic regimens used in intensive care units (ICUs) and associated with improved patient outcome. Controversy exists regarding the relative effects of both measures on patient outcome and antibiotic resistance. OBJECTIVE: To compare the effects of SDD and SOD, applied as unit-wide interventions, on antibiotic resistance and patient outcome...
October 8, 2014: JAMA: the Journal of the American Medical Association
Richard Price, Graeme MacLennan, John Glen
OBJECTIVES: To determine the effect on mortality of selective digestive decontamination, selective oropharyngeal decontamination, and topical oropharyngeal chlorhexidine in adult patients in general intensive care units and to compare these interventions with each other in a network meta-analysis. DESIGN: Systematic review, conventional meta-analysis, and network meta-analysis. Medline, Embase, and CENTRAL were searched to December 2012. Previous meta-analyses, conference abstracts, and key journals were also searched...
March 31, 2014: BMJ: British Medical Journal
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