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Utility of lactic acid and its backround

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6 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
Dimitrios Velissaris, Vasilios Karamouzos, Nikolaos Ktenopoulos, Charalampos Pierrakos, Menelaos Karanikolas
Introduction. Sepsis and its consequences such as metabolic acidosis are resulting in increased mortality. Although correction of metabolic acidosis with sodium bicarbonate seems a reasonable approach, there is ongoing debate regarding the role of bicarbonates as a therapeutic option. Methods. We conducted a PubMed literature search in order to identify published literature related to the effects of sodium bicarbonate treatment on metabolic acidosis due to sepsis. The search included all articles published in English in the last 35 years...
2015: Critical Care Research and Practice
Anita J Reddy, Simon W Lam, Seth R Bauer, Jorge A Guzman
In hospitalized patients, elevated serum lactate levels are both a marker of risk and a target of therapy. The authors describe the mechanisms underlying lactate elevations, note the risks associated with lactic acidosis, and outline a strategy for its treatment.
September 2015: Cleveland Clinic Journal of Medicine
Jason Chertoff, Michael Chisum, Bryan Garcia, Jorge Lascano
Over the last two decades, there have been vast improvements in sepsis-related outcomes, largely resulting from the widespread adoption of aggressive fluid resuscitation and infection control. With increased understanding of the pathophysiology of sepsis, novel diagnostics and resuscitative interventions are being discovered. In recent years, few diagnostic tests like lactate have engendered more attention and research in the sepsis arena. Studies highlighting lactate's prognostic potential for mortality and other outcomes are ubiquitous and largely focus on the early stage of sepsis management, defined as the initial 6 h and widely referred to as the "golden hours...
2015: Journal of Intensive Care
Adam J Singer, Merry Taylor, Anna Domingo, Saad Ghazipura, Adam Khorasonchi, Henry C Thode, Nathan I Shapiro
BACKGROUND: Early identification of sepsis and initiation of aggressive treatment saves lives. However, the diagnosis of sepsis may be delayed in patients without overt deterioration. Clinical screening tools and lactate levels may help identify sepsis patients at risk for adverse outcomes. OBJECTIVES: The objective was to determine the diagnostic characteristics of a clinical screening tool in combination with measuring early bedside point-of-care (POC) lactate levels in emergency department (ED) patients with suspected sepsis...
August 2014: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Michael A Puskarich, Alan E Jones
No abstract text is available yet for this article.
September 2014: Critical Care Medicine
Jan Bakker, Maarten Wn Nijsten, Tim C Jansen
Increased blood lactate levels (hyperlactataemia) are common in critically ill patients. Although frequently used to diagnose inadequate tissue oxygenation, other processes not related to tissue oxygenation may increase lactate levels. Especially in critically ill patients, increased glycolysis may be an important cause of hyperlactataemia. Nevertheless, the presence of increased lactate levels has important implications for the morbidity and mortality of the hyperlactataemic patients. Although the term lactic acidosis is frequently used, a significant relationship between lactate and pH only exists at higher lactate levels...
May 10, 2013: Annals of Intensive Care
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