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126 papers 100 to 500 followers
By Erica Yama Nephrologist
https://www.readbyqxmd.com/read/28456346/management-of-gout-and-hyperuricemia-in-ckd
#1
Ana Beatriz Vargas-Santos, Tuhina Neogi
Hyperuricemia and gout, the clinical manifestation of monosodium urate crystal deposition, are common in patients with chronic kidney disease (CKD). Although the presence of CKD poses additional challenges in gout management, effective urate lowering is possible for most patients with CKD. Initial doses of urate-lowering therapy are lower than in the non-CKD population, whereas incremental dose escalation is guided by regular monitoring of serum urate levels to reach the target level of <6mg/dL (or <5mg/dL for patients with tophi)...
April 26, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28028051/predicting-5-year-risk-of-rrt-in-stage-3-or-4-ckd-development-and-external-validation
#2
Emily B Schroeder, Xiuhai Yang, Micah L Thorp, Brent M Arnold, David C Tabano, Amanda F Petrik, David H Smith, Robert W Platt, Eric S Johnson
BACKGROUND AND OBJECTIVES: Only a minority of patients with CKD progress to renal failure. Despite the potential benefits of risk stratification in the CKD population, risk prediction models are not routinely used. Our objective was to develop and externally validate a clinically useful and pragmatic prediction model for the 5-year risk of progression to RRT in stage 3 or 4 CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used a retrospective cohort design...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28126237/kidney-disease-and-the-westernization-and-industrialization-of-food
#3
REVIEW
Holly Kramer
The industrialization of food in the United States has led to lower prices, and families now spend a smaller percentage of their total income on food compared with past generations. The decline in prices for food commodities has led to sharp increases in food consumption, with average caloric intake in the United States now more than 500 calories higher per day compared to the 1970s. This increase in total food consumption has fueled the ongoing obesity epidemic, which in turn has likely played a role in the epidemic of end-stage renal disease during the last 2 decades...
January 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28132720/kidney-disease-population-health-management-in-the-era-of-accountable-care-a-conceptual-framework-for-optimizing-care-across-the-ckd-spectrum
#4
Mallika L Mendu, Sushrut S Waikar, Sandhya K Rao
Since its passage in 2010, the Affordable Care Act has led to the creation of numerous accountable care organizations that face the challenge of transforming the traditional care delivery model to provide more patient-centered, high-quality, and low-cost care. Complex patients, including those with chronic kidney disease (CKD), present the most challenges and opportunities. CKD is a condition with significant morbidity, mortality, and cost and thought to be partly secondary to known gaps in care delivery. Successful population management for CKD requires consideration of the needs of patients at all phases of the disease...
January 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26994567/proton-pump-inhibitors-and-chronic-kidney-disease-is-it-time-to-sound-the-alarm
#5
EDITORIAL
Christina M Wyatt
Proton pump inhibitors are widely used worldwide for the management of gastroesophageal reflux, but have been associated with the development of interstitial nephritis and acute kidney injury. A large observational study using data from the Atherosclerosis Risk in Communities cohort and the Geisinger Health System demonstrates an association between the use of proton pump inhibitors and chronic kidney disease. Although the study does not prove causality, the robustness of the findings in two cohorts suggests a need for further study and reevaluation of the safety of these agents for widespread, non-prescription use...
April 2016: Kidney International
https://www.readbyqxmd.com/read/26894033/comprehensive-approach-to-diabetic-nephropathy
#6
REVIEW
Bancha Satirapoj, Sharon G Adler
Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with diabetes. This complication reflects a complex pathophysiology, whereby various genetic and environmental factors determine susceptibility and progression to end-stage renal disease. DN should be considered in patients with type 1 diabetes for at least 10 years who have microalbuminuria and diabetic retinopathy, as well as in patients with type 1 or type 2 diabetes with macroalbuminuria in whom other causes for proteinuria are absent...
September 2014: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/26848303/high-water-intake-and-progression-of-chronic-kidney-diseases
#7
REVIEW
Hoon Young Choi, Hyeong Cheon Park, Sung Kyu Ha
Impact of water intake on the courses of chronic kidney and urinary tract diseases, such as urolithiasis, urinary tract infections, chronic kidney diseases (CKD), autosomal dominant polycystic kidney diseases and bladder cancer, has recently been studied. It still remains controversial whether increased water intake slows the progression of CKD or not. However, high water intake suppresses plasma levels of arginine vasopressin (AVP), which is expected to be beneficial for the preservation of the kidney function...
December 2015: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/26893577/phosphate-binders-for-the-treatment-of-chronic-kidney-disease-role-of-iron-oxyhydroxide
#8
REVIEW
Valeria Cernaro, Domenico Santoro, Antonio Lacquaniti, Giuseppe Costantino, Luca Visconti, Antoine Buemi, Michele Buemi
Chronic kidney disease-mineral bone disorder is frequent in patients with renal failure. It is characterized by abnormalities in mineral and bone metabolism with resulting hyperphosphatemia, low serum vitamin D, secondary hyperparathyroidism, altered bone morphology and strength, higher risk of bone fractures, and development of vascular or other soft tissue calcifications. Besides the recommendation to reduce phosphorus dietary intake, many drugs are currently available for the treatment of calcium/phosphate imbalance...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/26364947/autosomal-dominant-polycystic-kidney-disease
#9
REVIEW
Jonathan Silverman, Chaitanya Desai, Edgar V Lerma
No abstract text is available yet for this article.
October 2015: Disease-a-month: DM
https://www.readbyqxmd.com/read/26518114/mineral-metabolism-in-chronic-kidney-disease
#10
REVIEW
Malgorzata Kochanek, Albara Said, Edgar V Lerma
No abstract text is available yet for this article.
October 2015: Disease-a-month: DM
https://www.readbyqxmd.com/read/26798149/mechanism-of-metformin-a-tale-of-two-sites
#11
Ruisheng Song
No abstract text is available yet for this article.
February 2016: Diabetes Care
https://www.readbyqxmd.com/read/26487769/a-systematic-review-and-meta-analysis-of-outcomes-of-pregnancy-in-ckd-and-ckd-outcomes-in-pregnancy
#12
REVIEW
Jing-Jing Zhang, Xin-Xin Ma, Li Hao, Li-Jun Liu, Ji-Cheng Lv, Hong Zhang
BACKGROUND AND OBJECTIVES: We undertook a systematic review and meta-analysis of published cohort studies and case-control studies to estimate (1) the risk of pregnancy complications among patients with CKD versus those without CKD and (2) the risk of CKD progression among pregnant patients versus nonpregnant controls with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We searched electronic databases for studies published between 1946 and 2014, and we reviewed articles using validity criteria...
November 6, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26709109/the-challenge-of-providing-renal-replacement-therapy-in-developing-countries-the-latin-american-perspective
#13
Gregorio T Obrador, Ximena Rubilar, Evandro Agazzi, Janette Estefan
The costs of health care place developing countries under enormous economic pressure. Latin America is a region characterized by wide ethnic and per capita gross domestic product variations among different countries. Chronic kidney failure prevalence and incidence, as well as provision of renal replacement therapy (RRT), have increased in all Latin American countries over the last 20 years. From an ethical point of view, life-sustaining therapies such as RRT should be available to all patients with chronic kidney disease who might benefit...
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26776539/approach-to-the-treatment-of-chronic-metabolic-acidosis-in-ckd
#14
Kalani L Raphael
Chronic metabolic acidosis is not uncommon in patients with chronic kidney disease (CKD). Clinical practice guidelines suggest that clinicians administer alkali to maintain serum bicarbonate level at a minimum of 22 mEq/L to prevent the effects of acidosis on bone demineralization and protein catabolism. Small interventional studies support the notion that correcting acidosis slows CKD progression as well. Furthermore, alkaline therapy in persons with CKD and normal bicarbonate levels may also preserve kidney function...
April 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26763385/diagnosis-and-management-of-iron-deficiency-in-ckd-a-summary-of-the-nice-guideline-recommendations-and-their-rationale
#15
Laura E K Ratcliffe, Wayne Thomas, Jessica Glen, Smita Padhi, Ben A J Pordes, David Wonderling, Roy Connell, Suzanne Stephens, Ashraf I Mikhail, Damian G Fogarty, Jan K Cooper, Belinda Dring, Mark A J Devonald, Chris Brown, Mark E Thomas
The UK-based National Institute for Health and Care Excellence (NICE) has updated its guidance on iron deficiency and anemia management in chronic kidney disease. This report outlines the recommendations regarding iron deficiency and their rationale. Serum ferritin alone or transferrin saturation alone are no longer recommended as diagnostic tests to assess iron deficiency. Red blood cell markers (percentage hypochromic red blood cells, reticulocyte hemoglobin content, or reticulocyte hemoglobin equivalent) are better than ferritin level alone at predicting responsiveness to intravenous iron...
April 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26752337/proton-pump-inhibitor-use-and-the-risk-of-chronic-kidney-disease
#16
MULTICENTER STUDY
Benjamin Lazarus, Yuan Chen, Francis P Wilson, Yingying Sang, Alex R Chang, Josef Coresh, Morgan E Grams
IMPORTANCE: Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI use and chronic kidney disease (CKD). OBJECTIVE: To quantify the association between PPI use and incident CKD in a population-based cohort. DESIGN, SETTING, AND PARTICIPANTS: In total, 10,482 participants in the Atherosclerosis Risk in Communities study with an estimated glomerular filtration rate of at least 60 mL/min/1...
February 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26759045/iron-management-in-chronic-kidney-disease-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#17
Iain C Macdougall, Andreas J Bircher, Kai-Uwe Eckardt, Gregorio T Obrador, Carol A Pollock, Peter Stenvinkel, Dorine W Swinkels, Christoph Wanner, Günter Weiss, Glenn M Chertow
Before the introduction of erythropoiesis-stimulating agents (ESAs) in 1989, repeated transfusions given to patients with end-stage renal disease caused iron overload, and the need for supplemental iron was rare. However, with the widespread introduction of ESAs, it was recognized that supplemental iron was necessary to optimize hemoglobin response and allow reduction of the ESA dose for economic reasons and recent concerns about ESA safety. Iron supplementation was also found to be more efficacious via intravenous compared to oral administration, and the use of intravenous iron has escalated in recent years...
January 2016: Kidney International
https://www.readbyqxmd.com/read/26759052/nephrology-crossword-innovative-renal-pathology-for-precision-diagnosis
#18
Jeffrey B Tompkins, Banu Sis
No abstract text is available yet for this article.
January 2016: Kidney International
https://www.readbyqxmd.com/read/26597304/acid-base-homeostasis
#19
REVIEW
L Lee Hamm, Nazih Nakhoul, Kathleen S Hering-Smith
Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance. This function of the kidneys has two components: reabsorption of virtually all of the filtered HCO3(-) and production of new bicarbonate to replace that consumed by normal or pathologic acids...
December 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26708193/gfr-as-the-gold-standard-estimated-measured-and-true
#20
EDITORIAL
Andrew S Levey, Lesley A Inker
No abstract text is available yet for this article.
January 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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