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Asma

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By Roberto Garay-Cabada Pediatrics , Fellow in pediatric Pulmonology
https://www.readbyqxmd.com/read/27845237/early-life-farm-exposures-and-adult-asthma-and-atopy-in-the-agricultural-lung-health-study
#1
John S House, Annah B Wyss, Jane A Hoppin, Marie Richards, Stuart Long, David M Umbach, Paul Henneberger, Laura E Beane Freeman, Dale P Sandler, Elizabeth Long O'Connell, Christie Barker Cummings, Stephanie J London
BACKGROUND: Previous studies, mostly from Europe, suggest that early-life farming exposures protect against childhood asthma and allergy; few data exist on asthma and allergy in adults. OBJECTIVE: To examine associations between early-life farming exposures and current asthma and atopy in an older adult US farming population. METHODS: We analyzed data from 1,746 farmers and 1,555 spouses (mean age=63) from a case-control study nested within the Agricultural Health Study...
November 11, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27785078/anti-inflammatory-dosing-of-theophylline-in-the-treatment-of-status-asthmaticus-in-children
#2
Nemr S Eid, Adrian O'Hagan, Scott Bickel, Ronald Morton, Sarah Jacobson, John A Myers
BACKGROUND: Low-dose theophylline has been recognized for its ability to restore histone deacetylase-2 activity which leads to improved steroid responsiveness and thus improved clinical outcome. We retrospectively evaluated the effect of low-dose theophylline therapy in pediatric patients hospitalized for an acute asthma exacerbation as a proof of concept study. METHODS: We compared patients who received low-dose theophylline (5-7 mg/kg/day) in addition to current standard of care to patients who were treated with current standard of care alone...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27741157/the-role-of-vitamin-d-in-allergic-diseases-in-children
#3
Michele Miraglia Del Giudice, Annalisa Allegorico
The role of vitamin D in calcium and phosphate homeostasis is well known; however, in addition to traditional functions, vitamin D modulates a variety of processes, and evidence shows that it has an important role in different allergic diseases such as asthma, atopic dermatitis, and food allergy. Vitamin D acts by binding to the vitamin D receptor, which is present in a variety of tissues; for this reason it is considered a hormone. One of the most important functions is to modulate the immune system response, both innate and adaptive, by suppressing Th2-type response and increasing natural killer cells...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27775836/allergy-in-severe-asthma
#4
Stefano R Del Giacco, Arzu Bakirtas, Elizabeth Bel, Adnan Custovic, Zuzana Diamant, Eckard Hamelmann, Enrico Heffler, Ömer Kalayci, Sejal Saglani, Svetlana Sergejeva, Sven Seys, Angela Simpson, Leif Bjermer
It is well recognized that atopic sensitisation is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term "Severe Asthma" encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming "uncontrolled", or whose disease remains "uncontrolled" despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations...
October 24, 2016: Allergy
https://www.readbyqxmd.com/read/27723364/effectiveness-of-air-purifier-on-health-outcomes-and-indoor-particles-in-homes-of-children-with-allergic-diseases-in-fresno-california-a-pilot-study
#5
Hye-Kyung Park, Kai-Chung Cheng, Afua O Tetteh, Lynn M Hildemann, Kari C Nadeau
OBJECTIVE: Epidemiologic studies indicate that indoor air pollution is correlated with morbidity caused by allergic diseases. We evaluated the effectiveness of reducing the levels of indoor fine particulate matter <2.5 micrometer diameter (PM2.5) in Fresno, California using air purifiers on health outcomes in children with asthma and/or allergic rhinitis. METHODS: The active group (with air purifiers) and the control group consisted of eight houses each. Air purifiers were installed in the living rooms and bedrooms of the subjects in the active group during the entire 12-week study duration...
October 10, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27612945/comorbid-disorders-associated-with-asthma-in-children-in-germany-national-analysis-of-pediatric-primary-care-data
#6
Louis Jacob, Thomas Keil, Karel Kostev
BACKGROUND: Using routine healthcare data, the goal of this study was to examine the association between asthma and comorbid disorders in children in Germany. METHODS: Patients with a diagnosis of asthma documented by a German pediatrician in 2015 were identified. Demographic data included age and gender. Patients younger than 6 and older than 17 and individuals followed for less than a year before index date were excluded. Each patient was matched for age, sex, and physician with an asthma-free control...
October 5, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27622699/randomized-trial-of-once-daily-fluticasone-furoate-in-children-with-inadequately-controlled-asthma
#7
Amanda J Oliver, Ronina A Covar, Caroline H Goldfrad, Ryan M Klein, Søren E Pedersen, Christine A Sorkness, Susan A Tomkins, César Villarán, Jonathan Grigg
OBJECTIVE: To evaluate the dose-response, efficacy, and safety of fluticasone furoate (FF; 25 µg, 50 µg, and 100 µg), administered once daily in the evening during a 12-week treatment period to children with inadequately controlled asthma. STUDY DESIGN: This was a Phase IIb, multicenter, stratified, randomized, double-blind, double-dummy, parallel-group, placebo- and active-controlled study in children aged 5-11 years with inadequately controlled asthma...
September 9, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27587561/childhood-obesity-in-relation-to-poor-asthma-control-and-exacerbation-a-meta-analysis
#8
Fariba Ahmadizar, Susanne J H Vijverberg, Hubertus G M Arets, Anthonius de Boer, Jason E Lang, Meyer Kattan, Colin N A Palmer, Somnath Mukhopadhyay, Steve Turner, Anke H Maitland-van der Zee
To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex.A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies)...
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27588581/inhaled-short-acting-bronchodilators-for-managing-emergency-childhood-asthma-an-overview-of-reviews
#9
M Pollock, I P Sinha, L Hartling, B H Rowe, S Schreiber, R M Fernandes
International guidelines provide conflicting recommendations on how to use bronchodilators to manage childhood acute wheezing conditions in the emergency department (ED), and there is variation within and among countries in how these conditions are managed. This may be reflective of uncertainty about the evidence. This overview of systematic reviews (SRs) aimed to synthesize, appraise, and present all SR evidence on the efficacy and safety of inhaled short-acting bronchodilators to treat asthma and wheeze exacerbations in children 0-18 years presenting to the ED...
October 5, 2016: Allergy
https://www.readbyqxmd.com/read/27405740/does-adenoid-hypertrophy-affect-disease-severity-in-children-with-allergic-rhinitis
#10
Mahmut Dogru, Muhammed Fatih Evcimik, Omer Faruk Calim
Our study aims to evaluate the presence of adenoid hypertrophy (AH) in children with allergic rhinitis (AR) and the association of AH disease severity and clinical laboratory finding from retrospective, cross-sectional, and nonrandomized trial. The study included 566 children being treated and followed up for allergic rhinitis. Skin prick test for the same allergens was performed for all patients. Adenoid tissue was analyzed by an ENT specialist and the diagnosis was confirmed based on the patient history, endoscopic physical examination and radiology...
July 12, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27370268/diagnosis-and-management-of-asthma-statement-on-the-2015-gina-guidelines
#11
Fritz Horak, Daniel Doberer, Ernst Eber, Elisabeth Horak, Wolfgang Pohl, Josef Riedler, Zsolt Szépfalusi, Felix Wantke, Angela Zacharasiewicz, Michael Studnicka
This statement was written by a group of pulmonologists and pediatric pulmonologists belonging to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) and ÖGKJ (Austrian Society for pediatric and adolescent medicine) to provide a concise overview of the latest updates in the 2015 GINA Guidelines and to include aspects that are specific to Austria.
August 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27387520/review-of-the-clinical-significance-of-respiratory-virus-infections-in-newborn-infants
#12
REVIEW
Raakel Luoto, Tuomas Jartti, Olli Ruuskanen, Matti Waris, Liisa Lehtonen, Terho Heikkinen
UNLABELLED: Respiratory viruses have been recognised as causative agents for a wide spectrum of clinical manifestations and severe respiratory compromise in neonates during birth hospitalisation. Early-life respiratory virus infections have also been shown to be associated with adverse long-term consequences. CONCLUSION: Preventing virus infections by intensifying hygiene measures and cohorting infected infants should be a major goal for neonatal intensive care units, as well as more common use of virus diagnostics...
October 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27215496/presence-of-rhinovirus-in-the-respiratory-tract-of-adolescents-and-young-adults-with-asthma-without-symptoms-of-infection
#13
L Öhrmalm, A Malinovschi, M Wong, P Levinson, C Janson, K Broliden, K Alving
BACKGROUND: Viral respiratory infections have been associated with up to 80% of wheezing episodes and asthma exacerbations. However, studies on the role of these viruses in asthmatic patients in the interval between exacerbations are sparse. This study aimed to determine the presence of respiratory viruses, without symptoms of infection, in the airways of young asthmatics as compared to healthy controls. MATERIAL AND METHODS: Patients 10-35 years of age with stable asthma and a group of healthy controls were analyzed regarding the presence of RNA from common respiratory viruses in nasopharyngeal aspirates by PCR...
June 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/26289061/recent-advances-in-paediatric-respiratory-medicine
#14
REVIEW
Andrew Turnbull, Ian M Balfour-Lynn
This review highlights important advances in paediatric respiratory medicine since 2014, excluding cystic fibrosis. It focuses mainly on the more common conditions, bronchopulmonary dysplasia, bronchiolitis and preschool wheezing, asthma, pneumonia and sleep, and highlights some of the rarer conditions such as primary ciliary dyskinesia and interstitial lung disease (ILD).
February 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27255476/response-to-pneumococcal-polysaccharide-vaccine-in-children-with-asthma-and-children-with-recurrent-respiratory-infections-and-healthy-children
#15
A Quezada, L Maggi, X Norambuena, J Inostroza, F Quevedo
BACKGROUND: To analyse specific immune response to the 23-valent pneumococcal polysaccharide vaccine by measuring pneumococcal antibodies in children with asthma and with respiratory recurrent infection (RRI) as compared to healthy children. METHODS: The study included 60 children, divided into three groups: 20 with asthma, 20 with RRI, and 20 healthy controls. Post-vaccination specific IgG antibodies against 10 pneumococcal serotypes (S1, S3, S4, S5, S6B, S9V, S14, S18C, S19F, and S23F) contained in the 23-valent pneumococcal polysaccharide vaccine (PPV) were measured...
July 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27187595/high-incidence-of-oral-corticosteroids-prescriptions-in-children-with-asthma-in-early-childhood
#16
Ali Arabkhazaeli, Susanne J H Vijverberg, Cornelis K van der Ent, Jan A M Raaijmakers, Anke H Maitland-van der Zee
OBJECTIVE: Severe asthma exacerbations are often treated with short courses of oral corticosteroids (OCS). This study assessed the incidence of OCS being prescribed in asthmatic children of various age groups and calculated their chances of receiving subsequent OCS prescriptions. METHODS: Longitudinal Dutch community pharmacy data of 2272 children who were regular users of asthma medication was analyzed retrospectively. Incidence rates for first, second and third prescriptions of OCS were calculated, stratified by age and sex...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27153740/removing-asthma-triggers-and-improving-children-s-health-the-asthma-partnership-demonstration-project
#17
Kenneth J Gruber, Beth McKee-Huger, April Richard, Brett Byerly, Jana L Raczkowski, Thomas C Wall
BACKGROUND: Studies have revealed the efficacy of home-based environmental interventions on reduction of asthma symptoms as a strategy for managing asthma in children. A focus on education and behavior change alone is generally too limited to reduce exposure to asthma triggers that exist because of adverse housing conditions. OBJECTIVE: To demonstrate that housing conditions as a focus of a health intervention should be considered more widely as an effective means of addressing serious health problems such as asthma...
May 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27144330/atopy-but-not-obesity-is-associated-with-asthma-severity-among-children-with-persistent-asthma
#18
Kim D Lu, Wanda Phipatanakul, Matthew S Perzanowski, Susan Balcer-Whaley, Elizabeth C Matsui
BACKGROUND AND OBJECTIVE: Obesity is associated with an increased risk of asthma in children. Atopic sensitization is a major risk factor for asthma including severe asthma in children. It is unclear if obesity is associated with worse asthma control or severity in children and how its effects compare to atopy. We sought to examine relationships of weight status and atopy to asthma control and severity among a population of predominantly low income, minority children and adolescents with persistent asthma...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27144654/the-difference-in-amount-of-physical-activity-performed-by-children-with-and-without-asthma-a-systematic-review-and-meta-analysis
#19
Raisa Cassim, Jennifer J Koplin, Shyamali C Dharmage, Baddewithana C V Senaratna, Caroline J Lodge, Adrian J Lowe, Melissa A Russell
OBJECTIVE: Despite the benefits of a physically active lifestyle, some studies suggest fear of exacerbations by both children and their parents limit physical activity in children with asthma. We undertook a systematic review to quantify the difference in objectively measured physical activity levels of children and adolescents with and without asthma. DATA SOURCES: MEDLINE, PubMed and EMBASE. STUDY SELECTION: English language observational studies of children and adolescents to the age of 18 that compared objectively measured physical activity (accelerometer or pedometer devices) between those with asthma and without asthma...
November 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27130294/periostin-levels-and-eosinophilic-inflammation-in-poorly-controlled-asthma
#20
Jodie L Simpson, Ian A Yang, John W Upham, Paul N Reynolds, Sandra Hodge, Alan L James, Christine Jenkins, Matthew J Peters, Guiquan Jia, Cecile T J Holweg, Peter G Gibson
BACKGROUND: Periostin levels are associated with airway eosinophilia and are suppressed by corticosteroid treatment in asthma. This study sought to determine the relationship between serum and sputum periostin, airway inflammatory phenotype and asthma control. METHODS: Adults with poorly-controlled asthma (n = 83) underwent a clinical assessment, sputum induction and blood sampling. Dispersed sputum was used for a differential cell count and periostin assessment (ELISA)...
2016: BMC Pulmonary Medicine
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