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Daniel Bolliger, Manfred D Seeberger, Giovanna A L Lurati Buse, Peter Christen, Brian Rupinski, Lorenz G├╝rke, Miodrag Filipovic
BACKGROUND: Associations between preoperative elevation of brain natriuretic peptide (BNP) or postoperative elevation of cardiac troponins (cTn) with major adverse cardiac events (MACE) after major surgery have been shown previously. In this study, we evaluated the added value of preoperative BNP with postoperative cTn levels for the prediction of MACE in patients undergoing major vascular surgery. METHODS: This is a prospectively prespecified, secondary analysis of data from a cohort of 133 clinically stable patients undergoing major vascular surgery enrolled in a clinical trial evaluating the effectiveness of the sympathetic nervous system-inhibiting drug moxonidine on reducing MACE...
April 2009: Anesthesia and Analgesia
David A Morrow, Benjamin M Scirica, Marc S Sabatine, James A de Lemos, Sabina A Murphy, Petr Jarolim, Pierre Theroux, Christophe Bode, Eugene Braunwald
OBJECTIVES: We designed a prospective evaluation of the interaction between B-type natriuretic peptide (BNP) and the effect of ranolazine in patients with acute coronary syndromes (ACS) as part of a randomized, blinded, placebo-controlled trial. BACKGROUND: Ranolazine is believed to exert anti-ischemic effects by reducing myocardial sodium and calcium overload and consequently ventricular wall stress. BNP increases in response to increased wall stress and is a strong risk indicator in ACS...
March 23, 2010: Journal of the American College of Cardiology
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