Martin C Tammemägi, Hormuzd A Katki, William G Hocking, Timothy R Church, Neil Caporaso, Paul A Kvale, Anil K Chaturvedi, Gerard A Silvestri, Tom L Riley, John Commins, Christine D Berg
BACKGROUND: The National Lung Screening Trial (NLST) used risk factors for lung cancer (e.g., ≥30 pack-years of smoking and <15 years since quitting) as selection criteria for lung-cancer screening. Use of an accurate model that incorporates additional risk factors to select persons for screening may identify more persons who have lung cancer or in whom lung cancer will develop. METHODS: We modified the 2011 lung-cancer risk-prediction model from our Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial to ensure applicability to NLST data; risk was the probability of a diagnosis of lung cancer during the 6-year study period...
February 21, 2013: New England Journal of Medicine