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AMR

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4 papers 0 to 25 followers
https://www.readbyqxmd.com/read/25029384/differential-modulation-of-donor-specific-antibodies-after-b-cell-depleting-therapies-to-cure-chronic-antibody-mediated-rejection
#1
COMPARATIVE STUDY
Maxime Touzot, Gr├ęgoire Couvrat-Desvergnes, St├ęphanie Castagnet, Anne Cesbron, Karine Renaudin, Diego Cantarovich, Magali Giral
BACKGROUND: Donor-specific antibodies (DSA) are considered as reliable biomarkers for antibody-mediated rejection (ABMR) diagnosis. However, it is unclear whether DSA monitoring is necessary and could predict graft outcome after antirejection treatment. METHODS: We analyzed 28 non-sensitized kidney transplant patients with ABMR associated with de novo anti-human leukocyte antigen (HLA) DSA. Donor-specific antibody levels were measured by single antigen bead assays 12 months after antirejection therapy onset...
January 2015: Transplantation
https://www.readbyqxmd.com/read/24480655/is-there-a-role-for-detection-of-complement-binding-antibodies-in-kidney-transplantation
#2
EDITORIAL
Jayme E Locke, Dorry L Segev
No abstract text is available yet for this article.
April 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/24401076/diagnosis-and-management-of-antibody-mediated-rejection-current-status-and-novel-approaches
#3
REVIEW
A Djamali, D B Kaufman, T M Ellis, W Zhong, A Matas, M Samaniego
Advances in multimodal immunotherapy have significantly reduced acute rejection rates and substantially improved 1-year graft survival following renal transplantation. However, long-term (10-year) survival rates have stagnated over the past decade. Recent studies indicate that antibody-mediated rejection (ABMR) is among the most important barriers to improving long-term outcomes. Improved understanding of the roles of acute and chronic ABMR has evolved in recent years following major progress in the technical ability to detect and quantify recipient anti-HLA antibody production...
February 2014: American Journal of Transplantation
https://www.readbyqxmd.com/read/23615506/sequential-analysis-of-donor-specific-antibodies-and-pathological-findings-in-acute-antibody-mediated-rejection-in-a-rat-renal-transplantation-model
#4
Naoki Kohei, Tatsu Tanabe, Shigeru Horita, Kazuya Omoto, Hideki Ishida, Yutaka Yamaguchi, Kazunari Tanabe
Alloantibodies contribute significantly to renal transplant rejection by activation of complement and various cytokines with a variety of effector cells, and are a major cause of allograft loss. Although there is clinical evidence of antibody- and complement-mediated injury in renal transplantation, the mechanism of antibody-mediated rejection remains largely unknown. In order to understand the sequential production of antibodies and complement components, we presensitized recipient rats by skin transplantation...
October 2013: Kidney International
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