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189 papers 25 to 100 followers
By Xander Zuidema MD, pharmD, Anesthesiologist, intensivist, pain specialist
Sungmin Han, Dong Hwee Kim, Joohwan Sung, Hwasun Yang, Jong Woong Park, Inchan Youn
Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration...
November 28, 2018: Biochemical and Biophysical Research Communications
Matthias Hubert Morgalla
No abstract text is available yet for this article.
December 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Leonardo Dini, Martina Del Lungo, Francesco Resta, Michele Melchiorre, Valentina Spinelli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Annunziatina Laurino, Laura Sartiani, Raffaele Coppini, Guido Mannaioni, Elisabetta Cerbai, Maria Novella Romanelli
A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by the widespread distribution of these channels. However, tissue-specific expression of HCN isoforms varies significantly, HCN1 and HCN2 being considered as major players in DRG excitability. We characterized the pharmacological effect of a novel compound, MEL55A, able to block selectively HCN1/HCN2 isoforms, on DRG neuron excitability in-vitro and for its antiallodynic properties in-vivo ...
2018: Frontiers in Pharmacology
Pauline S Groenen, Noud van Helmond, Kenneth B Chapman
No abstract text is available yet for this article.
November 8, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Nadine Gravius, Shafqat R Chaudhry, Sajjad Muhammad, Azize Boström, Sascha Gravius, Thomas Randau, Dirk Scheele, Philipp Westhofen, Johannes Kruppenbacher, Birgit Stoffel-Wagner, Christian Maier, Anna Weidlich, Thomas L Yearwood, Krishnan V Chakravarthy, Jeffery M Kramer, Rene Hurlemann, Thomas M Kinfe
OBJECTIVES: Complex regional pain syndrome (CRPS) and associated comorbidities have been linked to a pro-inflammatory state driven by different mediators. Targeted dorsal root ganglion stimulation (DRGSTIM ) suppressed pain levels and improved functional capacity in intractable CRPS. However, clinical trials assessing the impact of DRG stimulation on the neuroimmune axis are lacking. METHODS: This study enrolled 24 subjects (12 refractory CRPS patients plus suitably matched healthy controls) and performed immunoassays of inflammatory mediators in saliva and serum along with score-based assessments of pain, mood, and sleep quality at baseline and after three months of selective L4-DRGSTIM ...
October 25, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Jan Willem Kallewaard, Harold Nijhuis, Frank Huygen, Frank Wille, Xander Zuidema, Johan van de Minkelis, Adil Raza
INTRODUCTION: Surgical lumbar discectomy is a commonly performed routine spinal procedure that is usually undertaken to alleviate lumbar radicular symptoms caused by a herniated intervertebral disc. Surgical lumbar discectomy can also lead to chronic postsurgical leg and/or back pain (failed back surgery syndrome [FBSS]), a condition that can be refractory to conventional medical management. Early clinical results on the use of dorsal root ganglion (DRG) stimulation for FBSS have supported the use of this treatment alternative...
September 30, 2018: Pain Practice: the Official Journal of World Institute of Pain
Lingli Liang, Yuan-Xiang Tao
AIMS: Histone acetylation and deacetylation are two histone posttranslational modifications that are usually controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Although HATs or HDACs Inhibitors could relieve pain hypersensitivities in chronic pain animal models, it is not clear on the expression of global histone acetylation in the dorsal root ganglion (DRG) or spinal dorsal horn in chronic pain conditions. MAIN METHODS: A spinal nerve ligation (SNL)-induced neuropathic pain model and a complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats were used to examine the expression of total acetyl-histone H3 (AcH3) and total acetyl-histone H4 (AcH4) by immunofluorescence or western blot...
October 15, 2018: Life Sciences
Eva Koetsier, Glenn Franken, Jacques Debets, Sander M J van Kuijk, Roberto S G M Perez, Bengt Linderoth, Elbert A J Joosten, Paolo Maino
AIMS: Conventional dorsal root ganglion stimulation (DRGS) is known to achieve better pain-paresthesia overlap of difficult-to-reach areas like the feet compared to dorsal column spinal cord stimulation (SCS). As in painful diabetic polyneuropathy (PDPN) pain is mostly present in the feet, we hypothesized that DRGS is more effective in relieving pain in PDPN when compared to SCS. METHODS: Diabetes was induced in female Sprague-Dawley rats with an intraperitoneal injection of 65 mg/kg of streptozotocin (STZ; n = 48)...
September 23, 2018: CNS Neuroscience & Therapeutics
Ya-Ling Zhang, Yi-Guo Liu, Qing Li, Xiang-Dong Wang, Xiao-Bo Zheng, Bao-Lin Yang, Bin Wan, Jian-Min Ma, Zeng-Xu Liu
1,8-cineole is a natural monoterpene cyclic ether present in eucalyptus and has been reported to exhibit anti-inflammatory and antioxidant effects. The therapeutic effects of 1,8-cineole on neuropathic pain and the molecular mechanisms of its pharmacological actions remain largely unknown. In the present study, we investigated the analgesic mechanisms of orally administered 1,8-cineole in a rat model of chronic constriction injury (CCI) and examined the drug-induced modulation of P2X3 receptor expression in dorsal root ganglia...
September 22, 2018: Neurochemistry International
Jingjing Yuan, Jing Wen, Shaogen Wu, Yuanyuan Mao, Kai Mo, Zhisong Li, Songxue Su, Hanwen Gu, Yanqiu Ai, Alex Bekker, Wei Zhang, Yuan-Xiang Tao
Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) after peripheral nerve injury. Transcription factors control gene expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a transcription factor, contributed to neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. Chronic constriction injury produced a time-dependent increase in the level of OCT1 protein in the ipsilateral L4/5 DRG, but not in the spinal cord...
October 18, 2018: Pain
Timothy R Deer, Jason E Pope, Tim J Lamer, Jay S Grider, David Provenzano, Timothy R Lubenow, James J FitzGerald, Corey Hunter, Steven Falowski, Dawood Sayed, Ganesan Baranidharan, Nikunj K Patel, Timothy Davis, Alex Green, Antonio Pajuelo, Lawrence J Epstein, Michael Harned, Liong Liem, Paul J Christo, Krishnan Chakravarthy, Christopher Gilmore, Frank Huygen, Eric Lee, Pankaj Metha, Harold Nijhuis, Denis G Patterson, Erika Petersen, Julie G Pilitsis, Jeffery J Rowe, Matthew P Rupert, Ioannis Skaribas, Jennifer Sweet, Paul Verrills, Derron Wilson, Robert M Levy, Nagy Mekhail
INTRODUCTION: The Neuromodulation Appropriateness Consensus Committee (NACC) is dedicated to improving the safety and efficacy of neuromodulation and thus improving the lives of patients undergoing neuromodulation therapies. With continued innovations in neuromodulation comes the need for evolving reviews of best practices. Dorsal root ganglion (DRG) stimulation has significantly improved the treatment of complex regional pain syndrome (CRPS), among other conditions. Through funding and organizational leadership by the International Neuromodulation Society (INS), the NACC reconvened to develop the best practices consensus document for the selection, implantation and use of DRG stimulation for the treatment of chronic pain syndromes...
September 24, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Chia-Hsieh Chang, Kuo-Hsiang Lu, Wei-Tso Lin, Shih-Ching Chen, Wen-Pin Shih, Chii-Wann Lin
OBJECTIVES: Radiofrequency has been used to suppress spasticity affecting motion in patients with cerebral palsy and spinal cord injury. This study tested spasticity suppression and locomotion change after pulsed radiofrequency (PRF) at the dorsal root ganglion of rats with spasticity. MATERIALS AND METHODS: Twenty-four rats that survived for 28 days after thoracic spinal cord injury and showed spasticity in the right hind limb were separated randomly to a PRF group or Sham operation group...
September 25, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Steven Falowski, Jason E Pope, Adil Raza
BACKGROUND: Peripheral neuropathy is a chronic pain disorder involving physical, chemical, or metabolic damage to peripheral nerves. Its pain can be intense and disabling. Dorsal root ganglion (DRG) stimulation is an effective treatment for neuropathic pain, including cases with the limited regional distributions that often characterize peripheral neuropathy. METHODS: A retrospective analysis was completed. Patients were included on the basis of having chronic intractable peripheral neuropathy of the legs and/or feet and responding successfully to a trial of DRG stimulation with leads at L4-S1...
September 28, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Timothy J Ness, Cary DeWitte, Jamie McNaught, Buffie Clodfelder-Miller, Xin Su
Bilateral electrical pudendal nerve stimulation (bPNS) reduces bladder hypersensitivity in rat models of bladder pain and anecdotally reduces pain in humans with pelvic pain of urologic origin. The spinal neurochemical mechanisms of this antinociception are unknown. In the present study, bladder hypersensitivity was produced by neonatal bladder inflammation in rat pups coupled with a second inflammatory insult as an adult. Visceromotor responses (VMRs; abdominal muscle contractions) to urinary bladder distension (UBD) were used as a nociceptive endpoint under urethane-isoflurane anesthesia...
November 1, 2018: Neuroscience Letters
Corey W Hunter, Dawood Sayed, Timothy Lubenow, Timothy Davis, Jonathan Carlson, Jeffery Rowe, Ralph Justiz, Tory McJunkin, Timothy Deer, Pankaj Mehta, Steven Falowski, Leo Kapural, Jason Pope, Nagy Mekhail
INTRODUCTION: Dorsal root ganglion stimulation (DRGS) is a powerful tool in the treatment of chronic, neuropathic pain. The premise of DRGS is similar to that of conventional spinal cord stimulation (cSCS), however, there is more variability in how it can be utilized. While it is this variability that likely gives it its versatility, DRGS is not as straightforward to implement as cSCS. The purpose of this study was to assess the efficacy of DRGS on a broad number of diagnoses, determine which dorsal root ganglia were associated with better outcomes for particular body parts/diagnoses, and evaluate what factors/parameters were associated with higher rates of trial success...
August 7, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Frank J P M Huygen, Liong Liem, Harold Nijhuis, William Cusack, Jeffery Kramer
OBJECTIVES: Dorsal root ganglion (DRG) stimulation is a recent neuromodulation option that has delivered safe, effective pain relief for a number of etiologies. This prospective observational study was intended to establish the effectiveness of this treatment in a typical real-world clinical context. MATERIALS AND METHODS: Participants with chronic, intractable pain of the trunk or lower limbs were recruited from multiple pain clinics in the Netherlands. Subjects were trialed and implanted with DRG stimulation systems...
August 5, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Corey W Hunter, Ajax Yang
INTRODUCTION: Chronic pelvic pain (CPP) is an elusive and complex neuropathic condition that is notoriously recalcitrant to treatment. The term "CPP" encompasses a number of treatment-resistant conditions like pudendal neuralgia, interstitial cystitis, coccygodynia, vulvodynia. CPP has been presented neuromodulators attempting to utilize conventional spinal cord stimulation (SCS), with constant frustration and high explant rates. Contrary to SCS, dorsal root ganglion stimulation (DRGS) delivers targeted target to focal areas, does not rely on paresthesias, and is able to reliably capture body parts like the pelvis making it an ideal modality for the treatment of CPP...
August 1, 2018: Neuromodulation: Journal of the International Neuromodulation Society
B Billet, K Hanssens, O De Coster, W Nagels, R L Weiner, R Wynendaele, N Vanquathem
OBJECTIVE: Evaluation of the efficacy of a wireless high-frequency stimulator placed over selected DRG of exiting nerve roots for the treatment of chronic low back pain. DESIGN: Feasibility. SUBJECTS: Six subjects with chronic, intractable back pain refractory to standard medical treatment. METHODS: Four stimulators (Freedom-4A) provided by Stimwave Technologies, were implanted over the DRG exiting nerve roots, bilaterally at both the T9 and L2 vertebral levels...
April 19, 2018: Acta Anaesthesiologica Scandinavica
Amina M Illias, Andrea C Gist, Haijun Zhang, Alyssa K Kosturakis, Patrick M Dougherty
Activation of innate immune mechanisms within the dorsal root ganglion and spinal dorsal horn has been shown to play a key role in the development of neuropathic pain including paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN). Here, we tested whether similar mechanisms are generalizable to oxaliplatin-induced CIPN. After a single intraperitoneal injection of 3 mg/kg oxaliplatin, mechanical withdrawal threshold and the expression of C-C chemokine ligand 2 (CCL2) and its receptor, CCR2, in the dorsal root ganglion were measured by behavioral testing and immunohistochemical staining, respectively...
July 2018: Pain
Alex J Clark, Guillermo Menendez, Mona AlQatari, Niral Patel, Erik Arstad, Giampietro Schiavo, Martin Koltzenburg
Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous system. Despite significant advances in our knowledge of sensory neuron physiology and ion channel expression, many commonly used techniques fail to accurately model the primary afferent neuron in its entirety...
July 2018: Pain
2018-02-10 22:27:31
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