collection
MENU ▼
Read by QxMD icon Read
search

Uric acid lowering and CKD progression

shared collection
7 papers 0 to 25 followers Uric acid lowering may prevent renal events in CKD - what's the evidence?
By Daniel Schwartz Passionate about knowledge translation http://qxmd.com/read
https://www.readbyqxmd.com/read/26290849/associations-between-hyperuricemia-and-chronic-kidney-disease-a-review
#1
REVIEW
Om Shankar Prasad Sah, Yu Xue Qing
CONTEXT: In human beings, uric acid is the poorly soluble circulating end product of the purine nucleotide metabolism. A reduction in the glomerular filtration rate (GFR) contributes to hyperuricemia, which is frequently observed in patients with chronic kidney disease (CKD). EVIDENCE ACQUISITION: Hyperuricemia is defined as a serum uric acid level > 7.0 mg/dL in males and > 6.0 mg/dL in females, while CKD is defined as kidney damage or a GFR < 60 mL/min/1...
May 2015: Nephro-urology Monthly
https://www.readbyqxmd.com/read/26185050/uric-acid-is-not-associated-with-decline-in-renal-function-or-time-to-renal-replacement-therapy-initiation-in-a-referred-cohort-of-patients-with-stage-iii-iv-and-v-chronic-kidney-disease
#2
Hakan Nacak, Merel van Diepen, Abdul R Qureshi, Juan J Carrero, Theo Stijnen, Friedo W Dekker, Marie Evans
BACKGROUND: Although many studies have suggested an association between higher uric acid (UA) and both development of chronic kidney disease (CKD) and faster decline in renal function in Stage I and II CKD, it is not clear whether this effect is consistent throughout higher CKD stages. The aim of this study was to investigate the association between baseline UA and renal outcomes in patients with established CKD (Stages III-V). METHODS: We analysed data in the Swedish Renal Registry-Chronic Kidney Disease (SRR-CKD), which is a nationwide registry of referred CKD patients...
December 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26233732/efficacy-of-febuxostat-for-slowing-the-gfr-decline-in-patients-with-ckd-and-asymptomatic-hyperuricemia-a-6-month-double-blind-randomized-placebo-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Dipankar Sircar, Soumya Chatterjee, Rajesh Waikhom, Vishal Golay, Arpita Raychaudhury, Suparna Chatterjee, Rajendra Pandey
BACKGROUND: Hyperuricemia is a putative risk factor for the progression of chronic kidney disease (CKD). We hypothesized that control of asymptomatic hyperuricemia may slow disease progression in CKD. STUDY DESIGN: This was a single-center, double-blind, randomized, parallel-group, placebo-controlled study. SETTING & PARTICIPANTS: Eligible participants were adults from Eastern India aged 18 to 65 years with CKD stages 3 and 4, with asymptomatic hyperuricemia...
December 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/25676011/renoprotective-effects-of-febuxostat-in-hyperuricemic-patients-with-chronic-kidney-disease-a-parallel-group-randomized-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Kenichi Tanaka, Masaaki Nakayama, Makoto Kanno, Hiroshi Kimura, Kimio Watanabe, Yoshihiro Tani, Yoshimitsu Hayashi, Koichi Asahi, Hiroyuki Terawaki, Tsuyoshi Watanabe
BACKGROUND: Hyperuricemia is associated with the onset of chronic kidney disease (CKD) and renal disease progression. Febuxostat, a novel, non-purine, selective xanthine oxidase inhibitor, has been reported to have a stronger effect on hyperuricemia than conventional therapy with allopurinol. However, few data are available regarding the clinical effect of febuxostat in patients with CKD. METHODS: A prospective, randomized, open-label, parallel-group trial was conducted in hyperuricemic patients with stage 3 CKD...
December 2015: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/25595565/allopurinol-and-progression-of-ckd-and-cardiovascular-events-long-term-follow-up-of-a-randomized-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Marian Goicoechea, Soledad Garcia de Vinuesa, Ursula Verdalles, Eduardo Verde, Nicolas Macias, Alba Santos, Ana Pérez de Jose, Santiago Cedeño, Tania Linares, Jose Luño
BACKGROUND: Asymptomatic hyperuricemia increases renal and cardiovascular (CV) risk. We previously conducted a 2-year, single-blind, randomized, controlled trial of allopurinol treatment that showed improved estimated glomerular filtration rate and reduced CV risk. STUDY DESIGN: Post hoc analysis of a long-term follow-up after completion of the 2-year trial. SETTING & PARTICIPANTS: 113 participants (57 in the allopurinol group and 56 in the control group) initially followed up for 2 years and 107 participants followed up to 5 additional years...
April 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/25791959/the-relationship-between-uric-acid-allopurinol-cardiovascular-events-and-kidney-disease-progression-a-step-forward
#6
EDITORIAL
Gianni Bellomo
No abstract text is available yet for this article.
April 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/24042021/effects-of-uric-acid-lowering-therapy-on-renal-outcomes-a-systematic-review-and-meta-analysis
#7
REVIEW
Bhadran Bose, Sunil V Badve, Swapnil S Hiremath, Neil Boudville, Fiona G Brown, Alan Cass, Janak R de Zoysa, Robert G Fassett, Randall Faull, David C Harris, Carmel M Hawley, John Kanellis, Suetonia C Palmer, Vlado Perkovic, Elaine M Pascoe, Gopala K Rangan, Robert J Walker, Giles Walters, David W Johnson
BACKGROUND: Non-randomized studies suggest an association between serum uric acid levels and progression of chronic kidney disease (CKD). The aim of this systematic review is to summarize evidence from randomized controlled trials (RCTs) concerning the benefits and risks of uric acid-lowering therapy on renal outcomes. METHODS: Medline, Excerpta Medical Database and Cochrane Central Register of Controlled Trials were searched with English language restriction for RCTs comparing the effect of uric acid-lowering therapy with placebo/no treatment on renal outcomes...
February 2014: Nephrology, Dialysis, Transplantation
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"