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Essential Urology

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192 papers 100 to 500 followers
By Axel Cayetano Urology Resident
https://www.readbyqxmd.com/read/28578607/abiraterone-plus-prednisone-in-metastatic-castration-sensitive-prostate-cancer
#1
Karim Fizazi, NamPhuong Tran, Luis Fein, Nobuaki Matsubara, Alfredo Rodriguez-Antolin, Boris Y Alekseev, Mustafa Özgüroğlu, Dingwei Ye, Susan Feyerabend, Andrew Protheroe, Peter De Porre, Thian Kheoh, Youn C Park, Mary B Todd, Kim N Chi
Background Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer. Methods In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 1199 patients to receive either androgen-deprivation therapy plus abiraterone acetate (1000 mg daily, given once daily as four 250-mg tablets) plus prednisone (5 mg daily) (the abiraterone group) or androgen-deprivation therapy plus dual placebos (the placebo group)...
June 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-disease
#2
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included...
May 10, 2017: Urology
https://www.readbyqxmd.com/read/28456350/what-are-the-benefits-and-harms-of-ureteroscopy-compared-with-shock-wave-lithotripsy-in-the-treatment-of-upper-ureteral-stones-a-systematic-review
#3
REVIEW
Tamsin Drake, Nikolaos Grivas, Saeed Dabestani, Thomas Knoll, Thomas Lam, Steven Maclennan, Ales Petrik, Andreas Skolarikos, Michael Straub, Christian Tuerk, Cathy Yuhong Yuan, Kemal Sarica
CONTEXT: Extracorporeal shock wave lithotripsy (SWL) and ureteroscopy (URS), with or without intracorporeal lithotripsy, are the most common treatments for upper ureteric stones. With advances in technology, it is unclear which treatment is most effective and/or safest. OBJECTIVE: To systematically review literature reporting benefits and harms of SWL and URS in the management of upper ureteric stones. EVIDENCE ACQUISITION: Databases including Medline, Embase, and the Cochrane library were searched from January 2000 to November 2014...
April 26, 2017: European Urology
https://www.readbyqxmd.com/read/28434676/meta-analysis-of-results-of-testosterone-therapy-on-sexual-function-based-on-international-index-of-erectile-function-scores
#4
Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci, Mario Maggi
CONTEXT: The interpretation of available clinical evidence related to the effect of testosterone (T) treatment (TTh) on sexual function has been inconsistent, in part due to the use of different and self-reported measures to assess outcomes. The International Index of Erectile Function (IIEF) is the most frequently used validated tool to assess male sexual function. OBJECTIVE: To perform a meta-analysis of available data evaluating the effect of TTh on male sexual function using IIEF as the primary outcome...
April 20, 2017: European Urology
https://www.readbyqxmd.com/read/28445190/cognitive-learning-and-its-future-in-urology-surgical-skills-teaching-and-assessment
#5
Somayeh B Shafiei, Ahmed A Hussein, Khurshid A Guru
PURPOSE OF REVIEW: The aim of this study is to provide an overview of the current status of novel cognitive training approaches in surgery and to investigate the potential role of cognitive training in surgical education. RECENT FINDINGS: Kinematics of end-effector trajectories, as well as cognitive state features of surgeon trainees and mentors have recently been studied as modalities to objectively evaluate the expertise level of trainees and to shorten the learning process...
July 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28437028/european-section-of-urotechnology-educational-video-on-fluoroscopic-guided-puncture-in-percutaneous-nephrolithotomy-all-techniques-step-by-step
#6
Iason Kyriazis, Evangelos Liatsikos, Odysseas Sopilidis, Panagiotis Kallidonis, Andreas Skolarikos
OBJECTIVE: To describe the most common fluoroscopic-guided access techniques during percutaneous nephrolithotomy (PCNL) in a step-by-step manner and to assist in the standardisation of their technique and terminology. METHODS: A high-quality animation video was created for each of the respective fluoroscopic techniques, focusing into the parallel projection of external surgical manoeuvres and their effect in the three-dimensional space of the kidney. RESULTS: Four predominant fluoroscopic-guided percutaneous access techniques are available, each with different advantages and limitations...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28411911/risk-assessment-in-small-renal-masses-a-review-article
#7
REVIEW
Maxine Sun, Malte Vetterlein, Lauren C Harshman, Steven L Chang, Toni K Choueiri, Quoc-Dien Trinh
The incidence of localized renal cell carcinoma (RCC) has been steadily increasing, in large part because of the increased use of imaging. Optimizing the management of localized RCC has become one of the leading priorities and foremost challenges within the urologic-oncologic community. Adequate risk stratification of patients following the diagnosis of localized RCC has become meaningful in deciding whether to treat, how to treat, and how intensively to treat. This article characterizes the existing risk assessment models that can be useful as treatment decision aids for patients with localized RCC...
May 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28411913/active-surveillance-for-the-small-renal-mass-growth-kinetics-and-oncologic-outcomes
#8
REVIEW
Benjamin T Ristau, Andres F Correa, Robert G Uzzo, Marc C Smaldone
Active surveillance for small renal masses (SRMs) is an accepted management strategy for patients with prohibitive surgical risk. Emerging prospectively collected data support the concept that a period of initial active surveillance in an adherent patient population with well-defined criteria for delayed intervention is safe. This article summarizes the literature describing growth kinetics of SRMs managed initially with observation and oncologic outcomes for patients managed with active surveillance. Existing clinical tools to determine and contextualize competing risks to mortality are explored...
May 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28411915/surgical-techniques-in-the-management-of-small-renal-masses
#9
REVIEW
Michael Daugherty, Gennady Bratslavsky
This article provides a review and outline of the various surgical techniques for small renal masses. It covers surgical approaches and compares outcomes of open versus minimally invasive surgery. The article discusses renal nephrometry scoring and renal ischemia at time of resection. Techniques for controlling the renal hilum and controlling blood flow to the kidney are described. Extirpative techniques for small renal masses are reviewed along with a comparison of outcomes. With careful adherence to key oncologic and surgical principles, negative margins, no complications, and no or minimal decline in renal functional outcomes can be achieved...
May 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28411919/complications-of-renal-surgery
#10
REVIEW
William T Berg, Jeffrey J Tomaszewski, Hailiu Yang, Anthony Corcoran
The incidence of the small renal mass continues to increase owing to the aging population and the ubiquity imaging. Most of these tumors are stage I tumors. Management strategies include surveillance, ablation, and extirpation. There is a wide body of literature favoring nephron-sparing approaches. Although nephron-sparing surgery may yield decreased long-term morbidity, it is not without its drawbacks, including a higher rate of complications. Urologists must be attuned to the complications of surgery and develop strategies to minimize risk...
May 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28424869/review-on-diagnosis-and-management-of-urolithiasis-in-pregnancy-an-esut-practical-guide-for-urologists
#11
REVIEW
Bhaskar K Somani, Athanasios Dellis, Evangellos Liatsikos, Andreas Skolarikos
PURPOSE: Management of urolithiasis in pregnancy can be challenging for most urologists with diagnostic and treatment dilemma to ensure the best outcome for both mother and fetus. We wanted to review the literature for urolithiasis in pregnancy with a practical management guide for urologists. METHODS: A non-systematic review of literature was carried out for all English language literature using Medline. To ensure a more comprehensive search, the review of diagnosis and management of pregnant patients with urolithiasis was carried out separately, by two authors independently...
April 19, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28412063/diagnostic-performance-of-magnetic-resonance-imaging-for-the-detection-of-bone-metastasis-in-prostate-cancer-a-systematic-review-and-meta-analysis
#12
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
CONTEXT: Magnetic resonance imaging (MRI) has been tested for detecting bone metastasis and has shown promising results. Yet, consensus has not been reached regarding whether it can replace the role of bone scintigraphy in this clinical setting or not. OBJECTIVE: To review the diagnostic performance of contemporary (≥1.5 T) MRI for the detection of bone metastasis in patients with prostate cancer. EVIDENCE ACQUISITION: MEDLINE and EMBASE were searched up to January 22, 2017...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28413126/consensus-statement-of-the-european-urology-association-and-the-european-urogynaecological-association-on-the-use-of-implanted-materials-for-treating-pelvic-organ-prolapse-and-stress-urinary-incontinence
#13
REVIEW
Christopher R Chapple, Francisco Cruz, Xavier Deffieux, Alfredo L Milani, Salvador Arlandis, Walter Artibani, Ricarda M Bauer, Fiona Burkhard, Linda Cardozo, David Castro-Diaz, Jean Nicolas Cornu, Jan Deprest, Alfons Gunnemann, Maria Gyhagen, John Heesakkers, Heinz Koelbl, Sheila MacNeil, Gert Naumann, Jan-Paul W R Roovers, Stefano Salvatore, Karl-Dietrich Sievert, Tufan Tarcan, Frank Van der Aa, Francesco Montorsi, Manfred Wirth, Mohamed Abdel-Fattah
CONTEXT: Surgical nonautologous meshes have been used for several decades to repair abdominal wall herniae. Implantable materials have been adopted for the treatment of female and male stress urinary incontinence (SUI) and female pelvic organ prolapse (POP). OBJECTIVE: A consensus review of existing data based on published meta-analyses and reviews. EVIDENCE ACQUISITION: This document summarises the deliberations of a consensus group meeting convened by the European Association of Urology (EAU) and the European Urogynecological Association, to explore the current evidence relating to the use of polypropylene (PP) materials used for the treatment of SUI and POP, with reference to the 2016 EAU guidelines (European Association of Urology 2016), the European Commission's SCENIHR report on the use of surgical meshes (SCENIHR 2015), other available high-quality evidence, guidelines, and national recommendations...
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28407301/impact-of-clean-intermittent-catheterization-on-quality-adjusted-life-years-qalys-in-spinal-cord-injury-patients-with-neurogenic-urinary-incontinence
#14
Jan Svihra, Jan Krhut, Roman Zachoval, Viera Svihrova, Jan Luptak
AIMS: The impact of clean intermittent catheterization (CIC) on quality adjusted life years (QALYs) gained in adults' spinal cord injury population with neurogenic urinary incontinence (UI). METHODS: Patients were recruited from the national registry January-June 2014. The inclusion criteria were adults, neurogenic UI due to spinal cord injury (SCI), use of collection devices and CIC for more than 6 months. The exclusion criteria were inability to perform CIC, cancer of the lower urinary tract and fistulas formation...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28401957/contemporary-management-of-patients-with-penile-cancer-and-lymph-node-metastasis
#15
REVIEW
Andrew Leone, Gregory J Diorio, Curtis Pettaway, Viraj Master, Philippe E Spiess
Penile cancer is a rare disease that causes considerable physical and psychological patient morbidity, especially at advanced stages. Patients with low-stage nodal metastasis can achieve durable survival with surgery alone, but those with extensive locoregional metastasis have overall low survival. Contemporary management strategies for lymph node involvement in penile cancer aim to minimize the morbidity associated with traditional radical inguinal lymphadenectomy through appropriate risk stratification while optimizing oncological outcomes...
June 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28384011/tadalafil-facilitates-the-distal-ureteral-stone-expulsion-a-meta-analysis
#16
Yunjin Bai, Yubo Yang, Xiaoming Wang, Yin Tang, Ping Han, Jia Wang
OBJECTIVE: To assess the efficacy and safety of tadalafil in facilitating the spontaneous passage of distal ureteral stones. METHODS: The relevant studies were identified by searching MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials up to November 2016. Randomized controlled trials evaluating effects of tadalafil for distal ureteral stones were included. RESULTS: Six publications involving 921 patients were included...
June 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28397958/the-us-preventive-services-task-force-2017-draft-recommendation-statement-on-screening-for-prostate-cancer-an-invitation-to-review-and-comment
#17
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry
No abstract text is available yet for this article.
May 16, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28366513/cost-of-new-technologies-in-prostate-cancer-treatment-systematic-review-of-costs-and-cost-effectiveness-of-robotic-assisted-laparoscopic-prostatectomy-intensity-modulated-radiotherapy-and-proton-beam-therapy
#18
REVIEW
Florian Rudolf Schroeck, Bruce L Jacobs, Sam B Bhayani, Paul L Nguyen, David Penson, Jim Hu
CONTEXT: Some of the high costs of robot-assisted radical prostatectomy (RARP), intensity-modulated radiotherapy (IMRT), and proton beam therapy may be offset by better outcomes or less resource use during the treatment episode. OBJECTIVE: To systematically review the literature to identify the key economic trade-offs implicit in a particular treatment choice for prostate cancer. EVIDENCE ACQUISITION: We systematically reviewed the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement and protocol...
March 30, 2017: European Urology
https://www.readbyqxmd.com/read/28393475/unprofessional-content-on-facebook-accounts-of-us-urology-residency-graduates
#19
Kevin Koo, Zita Ficko, E Ann Gormley
OBJECTIVE: To characterize unprofessional content on public Facebook accounts of contemporary US urology residency graduates. METHODS: Facebook was queried with the names of all urologists who graduated from US urology residency programmes in 2015 to identify publicly accessible profiles. Profiles were assessed for unprofessional or potentially objectionable content using a prospectively designed rubric, based on professionalism guidelines by the American Urological Association, the American Medical Association, and the Accreditation Council for Graduate Medical Education...
June 2017: BJU International
https://www.readbyqxmd.com/read/28392182/differences-in-cavernosal-artery-parameters-according-to-different-anatomic-sampling-locations-during-the-diagnosis-of-vascular-erectile-dysfunction-using-duplex-ultrasound
#20
Fabio Pezzoni, Fabrizio Ildefonso Scroppo, Giorgio Cavallini
OBJECTIVE: To establish a standard location for examining penile cavernosal arteries (CAs) using dynamic duplex Doppler ultrasound (PDDU) examination in the diagnosis of non-arterial erectile dysfunction (ED) or arterial insufficiency. PATIENTS AND METHODS: Two groups of 105 patients each were enrolled. The first group (age 56.3 ± 6.0 years) displayed clinical patterns of arterial insufficiency; the second group (age 35.2 ± 4.7 years) displayed clinical patterns of non-arterial ED...
April 6, 2017: Urology
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