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By Saeed G. Zavareh Internal medicine specialist
Vivian M Choi, Julien Herrou, Aaron L Hecht, Wei Ping Teoh, Jerrold R Turner, Sean Crosson, Juliane Bubeck Wardenburg
Bacteroides fragilis is the leading cause of anaerobic bacteremia and sepsis. Enterotoxigenic strains that produce B. fragilis toxin (BFT, fragilysin) contribute to colitis and intestinal malignancy, yet are also isolated in bloodstream infection. It is not known whether these strains harbor unique genetic determinants that confer virulence in extra-intestinal disease. We demonstrate that BFT contributes to sepsis in mice, and we identify a B. fragilis protease called fragipain (Fpn) that is required for the endogenous activation of BFT through the removal of its auto-inhibitory prodomain...
May 2016: Nature Medicine
Steven Q Simpson
No abstract text is available yet for this article.
May 2016: Chest
Clifford S Deutschman
No abstract text is available yet for this article.
May 2016: Critical Care Medicine
Peter A Ward
No abstract text is available yet for this article.
May 2016: Critical Care Medicine
J Randall Moorman, Douglas E Lake, Plamen Ch Ivanov
No abstract text is available yet for this article.
May 2016: Critical Care Medicine
Charles Guenancia, Gabriel Laurent, Rémi Bruyère, Jean-Pierre Quenot
No abstract text is available yet for this article.
May 2016: Critical Care Medicine
Richard P Wenzel, Michael B Edmond
New England Journal of Medicine, Volume 372, Issue 21, Page 2062-2063, May 2015.
May 21, 2015: New England Journal of Medicine
Raffaella Bosurgi
No abstract text is available yet for this article.
May 2015: Lancet Infectious Diseases
Ron Daniels
No abstract text is available yet for this article.
May 2015: Lancet Infectious Diseases
Elisabeth D Riviello, Vincent Sugira, Theogene Twagirumugabe
No abstract text is available yet for this article.
May 2015: Lancet Infectious Diseases
Jonathan Cohen, Jean-Louis Vincent, Neill K J Adhikari, Flavia R Machado, Derek C Angus, Thierry Calandra, Katia Jaton, Stefano Giulieri, Julie Delaloye, Steven Opal, Kevin Tracey, Tom van der Poll, Eric Pelfrene
Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments...
May 2015: Lancet Infectious Diseases
J P Thompson, T J Coats, M R Sims
No abstract text is available yet for this article.
June 2015: British Journal of Anaesthesia
Sisse Rye Ostrowski, Nicolai Haase, Rasmus Beier Müller, Morten Hylander Møller, Frank Christian Pott, Anders Perner, Pär Ingemar Johansson
INTRODUCTION: Patients with severe sepsis often present with concurrent coagulopathy, microcirculatory failure and evidence of vascular endothelial activation and damage. Given the critical role of the endothelium in balancing hemostasis, we investigated single-point associations between whole blood coagulopathy by thrombelastography (TEG) and plasma/serum markers of endothelial activation and damage in patients with severe sepsis. METHODS: A post-hoc multicenter prospective observational study in a subgroup of 184 patients from the Scandinavian Starch for Severe Sepsis/Septic Shock (6S) Trial...
2015: Critical Care: the Official Journal of the Critical Care Forum
Nicolás Quezada, Cristóbal Maiz, David Daroch, Ricardo Funke, Allan Sharp, Camilo Boza, Fernando Pimentel
BACKGROUND: Postoperative leaks are a dreaded complication after bariatric surgery (BS). Its treatment is based on nutritional support and sepsis control by antibiotics, collections drainage and/or prosthesis, and/or surgery. OBJECTIVES: The aim of this study is to report our experience with coated self-expandable endoscopic stents (SEES) for leaks treatment. SETTING: This study was performed in a University Hospital, (censored). METHODS: We performed a retrospective analysis of our BS database from January 2007 to December 2013...
October 2015: Obesity Surgery
Franz Ratzinger, Katharina Eichbichler, Michael Schuardt, Irene Tsirkinidou, Dieter Mitteregger, Helmuth Haslacher, Thomas Perkmann, Klaus G Schmetterer, Georg Doffner, Heinz Burgmann
PURPOSE: Fast diagnosis and initiation of appropriate antibiotic therapy is pivotal for the survival of sepsis patients. However, most studies on suspected sepsis patients are conducted in the intensive care unit or in the emergency room setting, neglecting the standard care setting. This study evaluated sepsis risk factors, microbiological accurateness of the initial empiric antimicrobial therapy and its effect on hospital mortality in standard care patients. METHODS: In this prospective observational cohort study, patients with clinically suspected sepsis meeting two or more SIRS criteria were screened on standard care wards...
June 2015: Infection
Zhongheng Zhang, Lin Chen, Hongying Ni
BACKGROUND AND OBJECTIVE: The effect of antipyretic therapy on mortality in patients with sepsis remains undetermined. The present study aimed to investigate the role of antipyretic therapy in ICU patients with sepsis by using a large clinical database. METHODS: The multiparameter intelligent monitoring in intensive care II (MIMIC- II) database was employed for the study. Adult patients with sepsis were included for analysis. Antipyretic therapy included antipyretic medication and external cooling...
2015: PloS One
Brynne A Sullivan, Karen D Fairchild
Despite vigilant clinical assessment of infants in the neonatal intensive care unit (NICU), diagnosis of sepsis and necrotizing enterocolitis often does not occur until an infant has significant hemodynamic compromise. Predictive monitoring involves analysis of vital signs and other clinical data to identify infants at highest risk and to detect early-stage illness, leading to timelier treatment and improved outcomes. The first vital-sign predictive monitoring device developed for sepsis detection in babies in the NICU is the heart rate characteristics index (HeRO) monitor, which continuously analyzes the electrocardiogram signal for low heart rate variability and transient decelerations...
August 2015: Seminars in Fetal & Neonatal Medicine
John H Griffin, Berislav V Zlokovic, Laurent O Mosnier
The homeostatic blood protease, activated protein C (APC), can function as (1) an antithrombotic on the basis of inactivation of clotting factors Va and VIIIa; (2) a cytoprotective on the basis of endothelial barrier stabilization and anti-inflammatory and antiapoptotic actions; and (3) a regenerative on the basis of stimulation of neurogenesis, angiogenesis, and wound healing. Pharmacologic therapies using recombinant human and murine APCs indicate that APC provides effective acute or chronic therapies for a strikingly diverse range of preclinical injury models...
May 7, 2015: Blood
Chunkui Zhou, Limin Wu, Jiang Wu, Hongliang Zhang
No abstract text is available yet for this article.
September 2014: Annals of Saudi Medicine
Min-Juei Tsai, Shuo-Ming Ou, Chia-Jen Shih, Pei-Wen Chao, Lan-Fu Wang, Yu-Ning Shih, Szu-Yuan Li, Shu-Chen Kuo, Yen-Tao Hsu, Yung-Tai Chen
BACKGROUND: Antiplatelet agents are widely used for cardiovascular disea ses, but their pleiotropic effects in sepsis are controversial. OBJECTIVE: To investigate the association between antiplatelet agents and the survival benefit for sepsis patients. DESIGN: A nationwide population-based cohort and nested case-control study. SETTING: Taiwan National Health Insurance database. PARTICIPANTS: All patients (age ≥18 years) who were hospitalized for sepsis between January 2000 and December 2010...
May 2015: Intensive Care Medicine
2015-04-05 21:55:08
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