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14 papers 100 to 500 followers
By Gustavo Pena Physician Assistant in Family Practice
Yasuo Ikeda, Kazuyuki Shimada, Tamio Teramoto, Shinichiro Uchiyama, Tsutomu Yamazaki, Shinichi Oikawa, Masahiro Sugawara, Katsuyuki Ando, Mitsuru Murata, Kenji Yokoyama, Naoki Ishizuka
IMPORTANCE: Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population. OBJECTIVE: To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors. DESIGN, SETTING, AND PARTICIPANTS: The Japanese Primary Prevention Project (JPPP) was a multicenter, open-label, randomized, parallel-group trial...
December 17, 2014: JAMA: the Journal of the American Medical Association
Helen P Booth, Toby A Prevost, Alison J Wright, Martin C Gulliford
BACKGROUND: Overweight and obesity have negative health effects. Primary care clinicians are best placed to intervene in weight management. Previous reviews of weight loss interventions have included studies from specialist settings. The aim of this review was to estimate the effect of behavioural interventions delivered in primary care on body weight in overweight and obese adults. METHODS: The review included randomized controlled trials (RCTs) of behavioural interventions in obese or overweight adult participants in a primary care setting, with weight loss as the primary outcome, and a minimum of 12 months of follow-up...
December 2014: Family Practice
Jill Jin
No abstract text is available yet for this article.
November 12, 2014: JAMA: the Journal of the American Medical Association
John R de Almeida, Gordon H Guyatt, Sachin Sud, Joanne Dorion, Michael D Hill, Michael R Kolber, Jane Lea, Sylvia Loong Reg, Balvinder K Somogyi, Brian D Westerberg, Chris White, Joseph M Chen
No abstract text is available yet for this article.
September 2, 2014: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
William R Hiatt, Robert J Smith
On October 16, 2013, the Endocrinologic and Metabolic Drugs Advisory Committee of the Food and Drug Administration (FDA) voted 9 to 2 against approval of Vascepa, a purified n–3 fatty acid formulation of ethyl eicosapentaenoic acid (EPA), for use as an adjunct to diet and in combination with a..
January 30, 2014: New England Journal of Medicine
Omar A Mahroo, Elizabeth M Graham
A 34-year-old man presented to the eye emergency department with reduced vision in the right eye that had developed that morning. He was well, apart from episodes of dizziness and dyspnea after exercise during the previous 4 months. These episodes had started 1 week after the patient had undergone..
June 19, 2014: New England Journal of Medicine
Sylvia Wassertheil-Smoller, Susan L Hendrix, Marian Limacher, Gerardo Heiss, Charles Kooperberg, Alison Baird, Theodore Kotchen, J David Curb, Henry Black, Jacques E Rossouw, Aaron Aragaki, Monika Safford, Evan Stein, Somchai Laowattana, W Jerry Mysiw
CONTEXT: The Women's Health Initiative (WHI) trial of estrogen plus progestin was stopped early because of adverse effects, including an increased risk of stroke in the estrogen plus progestin group. OBJECTIVE: To assess the effect of estrogen plus progestin on ischemic and hemorrhagic stroke and in subgroups, and to determine whether the effect of estrogen plus progestin was modified by baseline levels of blood biomarkers. DESIGN: Multicenter double-blind, placebo-controlled, randomized clinical trial involving 16 608 women aged 50 through 79 years with an average follow-up of 5...
May 28, 2003: JAMA: the Journal of the American Medical Association
Kortaro Tanaka, Yuichi Ishikawa, Mitsuhiro Yokoyama, Hideki Origasa, Masunori Matsuzaki, Yasushi Saito, Yuji Matsuzawa, Jun Sasaki, Shinichi Oikawa, Hitoshi Hishida, Hiroshige Itakura, Toru Kita, Akira Kitabatake, Noriaki Nakaya, Toshiie Sakata, Kazuyuki Shimada, Kunio Shirato
BACKGROUND AND PURPOSE: The JELIS trial examined the preventive effect of eicosapentaenoic acid (EPA) against coronary artery diseases. Hypercholesterolemic patients received statin only (no EPA group: n=9319) or statin with EPA (EPA group: n=9326) for around 5 years. EPA significantly suppressed the incidence of coronary events in previous analysis. Herein, we investigated the effects of EPA on the primary and secondary prevention of stroke. METHODS: We conducted a subanalysis of JELIS with respect to stroke incidence in the primary and secondary prevention subgroups defined as those without and with a prior history of stroke using Cox proportional hazard ratios, adjusted for baseline risk factor levels...
July 2008: Stroke; a Journal of Cerebral Circulation
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2014: American Family Physician
Donald M Lloyd-Jones, Martin G Larson, Eric P Leip, Alexa Beiser, Ralph B D'Agostino, William B Kannel, Joanne M Murabito, Ramachandran S Vasan, Emelia J Benjamin, Daniel Levy
BACKGROUND: Congestive heart failure (CHF) is an increasing public health problem. METHODS AND RESULTS: Among Framingham Heart Study subjects who were free of CHF at baseline, we determined the lifetime risk for developing overt CHF at selected index ages. We followed 3757 men and 4472 women from 1971 to 1996 for 124 262 person-years; 583 subjects developed CHF and 2002 died without prior CHF. At age 40 years, the lifetime risk for CHF was 21.0% (95% CI 18.7% to 23...
December 10, 2002: Circulation
Mickaël Tobalem, Ilker Uçkay
An obese 50-year-old man with no known medical history presented with a necrotizing infection of his right foot that had begun 10 days previously with lesions that he attributed to wearing new shoes. He was found to have diabetes (glycated hemoglobin level, 10.5%) with peripheral neuropathy; he was..
December 5, 2013: New England Journal of Medicine
Hanan Handor, Rajae Daoudi
A 25-year-old primigravida at 36 weeks of gestation presented with a 2-week history of headache, light flashes, and blurred vision in both eyes. Her corrected visual acuity was 20/40 in the right eye and 20/50 in the left eye. Funduscopic examination revealed bilateral grade 4 hypertensive..
February 20, 2014: New England Journal of Medicine
George Griffing
A 59-year-old man with long-standing hypertension presented with exertional chest pain. An electrocardiogram and cardiac stress testing were unremarkable. Coronary angiography, however, revealed substantial stenosis, and two stents were placed. The patient's recovery was uneventful, and he has..
March 6, 2014: New England Journal of Medicine
Neil J Stone, Jennifer G Robinson, Alice H Lichtenstein, David C Goff, Donald M Lloyd-Jones, Sidney C Smith, Conrad Blum, J Sanford Schwartz
DESCRIPTION: In November 2013, the American College of Cardiology and American Heart Association (ACC/AHA) released a clinical practice guideline on the treatment of blood cholesterol to reduce cardiovascular risk in adults. This synopsis summarizes the major recommendations. METHODS: In 2008, the National Heart, Lung, and Blood Institute convened the Adult Treatment Panel (ATP) IV to update the 2001 ATP-III cholesterol guidelines using a rigorous process to systematically review randomized, controlled trials (RCTs) and meta-analyses of RCTs that examined cardiovascular outcomes...
March 4, 2014: Annals of Internal Medicine
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