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125 papers 25 to 100 followers
By David Herrera Rheuma
Jason L Kubinak, June L Round
Disruptions to the microbiota can have pathological consequences, which highlights the need to understand the factors that contribute to its stability. Although decades of research have focused on the importance of IgA during pathogenic infection, much of the IgA that is generated in the gut targets the resident commensal microorganisms. Despite this observation, the role of antibodies in regulating microbiota composition remains controversial and poorly understood. Here we propose that antibodies generated in response to microbial colonization of the gut shape the composition of the microbiota to benefit the health of the host through a process that we term antibody-mediated immunoselection (AMIS)...
2016: Nature Reviews. Immunology
M U Martínez-Martínez, L M de G Llamazares-Azuara, D Martínez-Galla, P B Mandeville, F Valadez-Castillo, S Román-Acosta, J A Borjas-García, C Abud-Mendoza
OBJECTIVES: The objective of this paper was to evaluate correlations between kidney biopsy indexes (activity and chronicity) and urinary sediment findings; the secondary objective was to find which components of urinary sediment can discriminate proliferative from other classes of lupus nephritis. METHODS: Lupus nephritis patients scheduled for a kidney biopsy were included in our study. The morning before the kidney biopsy, we took urine samples from each patient...
September 29, 2016: Lupus
Tom Van de Wiele, Jens T Van Praet, Massimo Marzorati, Michael B Drennan, Dirk Elewaut
The human gut harbours a tremendously diverse and abundant microbial community that correlates with, and even modulates, many health-related processes. The mucosal interfaces are particularly active sites of microorganism-host interplay. Growing insight into the characteristic composition and functionality of the mucosal microbiota has revealed that the microbiota is involved in mucosal barrier integrity and immune function. This involvement affects proinflammatory and anti-inflammatory processes not only at the epithelial level, but also at remote sites such as the joints...
July 2016: Nature Reviews. Rheumatology
Mitch Leslie
No abstract text is available yet for this article.
July 1, 2016: Science
Elizabeth V Arkema, Kristin Palmsten, Christopher Sjöwall, Elisabet Svenungsson, Jane E Salmon, Julia F Simard
OBJECTIVE: To assess maternal and fetal outcomes associated with subclinical (pre-systemic lupus erythematosus [SLE] and SLE presenting up to 5 years postpartum) and prevalent maternal SLE during pregnancy compared with the general population. METHODS: This prospective cohort study used population-based Swedish registers to identify 13,598 women with first singleton pregnancies registered in the Medical Birth Register (551 prevalent SLE, 65 pre-SLE within 0-2 years, 133 pre-SLE within 2-5 years, and 12,847 general population)...
July 2016: Arthritis Care & Research
M Yates, R A Watts, I M Bajema, M C Cid, B Crestani, T Hauser, B Hellmich, J U Holle, M Laudien, M A Little, R A Luqmani, A Mahr, P A Merkel, J Mills, J Mooney, M Segelmark, V Tesar, K Westman, A Vaglio, N Yalçındağ, D R Jayne, C Mukhtyar
In this article, the 2009 European League Against Rheumatism (EULAR) recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have been updated. The 2009 recommendations were on the management of primary small and medium vessel vasculitis. The 2015 update has been developed by an international task force representing EULAR, the European Renal Association and the European Vasculitis Society (EUVAS). The recommendations are based upon evidence from systematic literature reviews, as well as expert opinion where appropriate...
September 2016: Annals of the Rheumatic Diseases
Ioannis Parodis, Laurent Arnaud, Jakob Gerhardsson, Agneta Zickert, Birgitta Sundelin, Vivianne Malmström, Elisabet Svenungsson, Iva Gunnarsson
Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE). It remains unclear whether antiphospholipid antibodies (aPL) alter the course of LN. We thus investigated the impact of aPL on short-term and long-term renal outcomes in patients with LN. We assessed levels of aPL cross-sectionally in SLE patients diagnosed with (n = 204) or without (n = 294) LN, and prospectively in 64 patients with active biopsy-proven LN (52 proliferative, 12 membranous), before and after induction treatment (short-term outcomes)...
2016: PloS One
Eun Ha Kang, Sang Jin Lee, Dana P Ascherman, Yun Jong Lee, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
OBJECTIVES: The aim was to compare standardized incidence ratios (SIRs) of cancers temporally related and unrelated to active myositis in patients with myositis. METHODS: Fifty-two cancer cases were identified in 281 myositis patients. SIRs of cancers having temporal overlap with the active phase of myositis [cancers concurrent with active myositis (CAM), n = 30] and cancers not having such temporal overlap [cancers non-concurrent with active myositis (CNM), n = 22] were compared in 281 patients...
September 2016: Rheumatology
Ellen F Carney
No abstract text is available yet for this article.
August 2016: Nature Reviews. Nephrology
Petr Broz, Vishva M Dixit
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders...
2016: Nature Reviews. Immunology
Steven N Goodman, Daniele Fanelli, John P A Ioannidis
The language and conceptual framework of "research reproducibility" are nonstandard and unsettled across the sciences. In this Perspective, we review an array of explicit and implicit definitions of reproducibility and related terminology, and discuss how to avoid potential misunderstandings when these terms are used as a surrogate for "truth."
June 1, 2016: Science Translational Medicine
S Manou-Stathopoulou, M G Robson
Rituximab is a chimeric anti-CD20 monoclonal antibody that is used as an immunosuppressive agent in cyclophosphamide refractory lupus nephritis to induce remission. Although uncontrolled case series suggest efficacy, this is not yet supported by evidence from prospective randomized controlled trials. The objective of this retrospective case series is to report the clinical outcome of seven patients who received rituximab for lupus nephritis in a single centre between 2011 and 2014. One patient had clinical evidence of an uncomplicated response to therapy...
October 2016: Lupus
T S Ferreira, F Reis, S Appenzeller
INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is a neurological complex disorder with many clinical associations and causative factors. It is important to recognize this condition because early diagnosis and treatment usually result in its complete resolution, radiological imaging becoming the key for the correct diagnosis. METHODS: We retrospectively reviewed charts and magnetic resonance imaging findings in the University of Campinas from January 2005 to July 2015, selecting three cases of patients with systemic lupus erythematosus syndrome who developed PRES, for whom risk factors, characteristics, magnetic resonance imaging findings and neurological resolution were analyzed...
October 2016: Lupus
N Ambrose, T A Morgan, J Galloway, Y Ionnoau, M W Beresford, D A Isenberg
OBJECTIVES: Significant differences have been reported in disease phenotype and severity of systemic lupus erythematosus (SLE) presenting in different age groups. Most indicate a more severe phenotype in juvenile-onset SLE (JSLE). There have been limited studies in older patients and no large studies looking at SLE across all age groups. METHODS: We assessed the effect of age of onset of SLE on the clinical phenotype by analysing data from two large UK cohorts (the UK JSLE Cohort and the UCLH SLE cohort)...
December 2016: Lupus
David Herrera van Oostdam, Marco U Martínez Martínez, Cuauhtémoc Oros-Ovalle, David Martínez-Gala, Gerardo T Jaimes Piñón, Carlos Abud Mendoza
The aim of this study is to determine the frequency and prognosis of IgG4 deposits in renal biopsy of patients with membranous lupus nephritis (MLN). This is a retrospective cohort study in which we included patients with class V alone or combined (III/V or IV/V) of lupus nephritis according to the 2004 ISN/RPS. All the patients included must have availability of renal tissue for immunohistochemistry analyses. We excluded other classes of lupus nephritis. The renal tissue was examined by a nephro-pathologist...
June 2016: Clinical Rheumatology
George C Tsokos
A shunting of glucose metabolism to the pentose phosphate pathway in rheumatoid arthritis T cells causes exhaustion of oxidants, enhanced cell proliferation, and differentiation toward the T helper 1 (TH1) and TH17 programs (Yanget al, this issue).
March 23, 2016: Science Translational Medicine
Demetrios N Kyriacou
No abstract text is available yet for this article.
March 15, 2016: JAMA: the Journal of the American Medical Association
Cecile M Yelnik, T Flint Porter, D Ware Branch, Carl A Laskin, Joan T Merrill, Marta M Guerra, Michael D Lockshin, Jill P Buyon, Michelle Petri, Lisa R Sammaritano, Mary D Stephenson, Mimi Y Kim, Jane E Salmon
OBJECTIVE: To measure variance in antiphospholipid antibody (aPL) levels during pregnancy and to determine if variation affects pregnancy outcomes. METHODS: We used data from the PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus) study, a multicenter prospective study of pregnant women with aPL and/or systemic lupus erythematosus (SLE). Antiphospholipid antibodies were considered present if any of the following were positive: anticardiolipin (aCL), anti-β2 -glycoprotein I (anti-β2 GPI) titers ≥40 IgG phospholipid (GPL) or IgM phospholipid (MPL) units, and/or lupus anticoagulant (LAC)...
August 2016: Arthritis & Rheumatology
Kwangwoo Kim, So-Young Bang, Young Bin Joo, Taehyeung Kim, Hye-Soon Lee, Changwon Kang, Sang-Cheol Bae
OBJECTIVE: Cyclophosphamide (CYC) is an immunosuppressant drug widely used to treat various diseases including lupus nephritis, but its efficacy highly varies from individual to individual. This pharmacogenomics association study searched for genetic variations associated with CYC efficacy. METHODS: Genome-wide association scan was performed for 109 Korean patients with systemic lupus erythematosus with lupus nephritis (classes III-V) who received intravenous CYC induction therapy...
June 2016: Journal of Rheumatology
Don L Goldenberg, Daniel J Clauw, Roy E Palmer, Andrew G Clair
Multiple pharmacotherapies are available for the treatment of fibromyalgia (FM), including opioid analgesics. We postulate that the mechanism of action of traditional opioids predicts their lack of efficacy in FM. Literature searches of the MEDLINE and Cochrane Library databases were conducted using the search term opioid AND fibromyalgia to identify relevant articles, with no date limitations set. Citation lists in returned articles and personal archives of references were also examined for additional relevant items, and articles were selected based on the expert opinions of the authors...
May 2016: Mayo Clinic Proceedings
2016-03-23 04:58:13
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