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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28104166/kidney-donor-risk-index-as-the-predictor-for-the-short-term-clinical-outcomes-after-kidney-transplant-from-deceased-donor-with-acute-kidney-injury
#1
H Jun, C W Jung, S Lim, M G Kim
BACKGROUND: The Kidney Donor Risk Index (KDRI) scoring system for deceased donors has been widely introduced for postoperative evaluation of graft function. We analyzed the usefulness of the KDRI in deceased donors with acute kidney injury (AKI). METHODS: Forty-nine recipients from deceased donors with AKI between January 2009 and December 2014 were reviewed retrospectively. Data collected from donor medical records included age, height, weight, hypertension or diabetes history, cause of death, serum creatinine (sCr), and donation after cardiac death...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28072755/strategies-for-an-expanded-use-of-kidneys-from-elderly-donors
#2
María José Pérez-Sáez, Núria Montero, Dolores Redondo-Pachón, Marta Crespo, Julio Pascual
The old-for-old allocation policy used for kidney transplantation (KT) has confirmed the survival benefit compared to remaining listed on dialysis. Shortage of standard donors has stimulated the development of strategies aimed to expand acceptance criteria, particularly of kidneys from elderly donors. We have systematically reviewed the literature on those different strategies. In addition to the review of outcomes of expanded criteria donor or advanced age kidneys, we assessed the value of the Kidney Donor Profile Index policy, preimplantation biopsy, dual KT, machine perfusion and special immunosuppressive protocols...
April 2017: Transplantation
https://www.readbyqxmd.com/read/27936521/perioperative-and-long-term-outcomes-in-octogenarians-after-kidney-transplantation-the%C3%A2-us-perspective%C3%A2
#3
Abhishek Ravinuthala, Xiaonan Mei, Michael Daily, Malay Shah, Analia Castellanos, Jonathan Berger, Roberto Gedaly
BACKGROUND: We aimed to study outcomes on octogenarian patients undergoing kidney transplantation in the US. METHODS: We queried the UNOS dataset from 1988 through 2013 and found 471 octogenarians transplanted during the study period. RESULTS: 86 (18.3%) were female and 385 (81.7%) were male with a mean age of 81.58 years. The octogenarians had a significantly higher incidence of diabetes, at 17.2% compared to 13.7% in the non-octogenarian group (p < 0...
February 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/27979990/dementia-and-alzheimer-s-disease-among-older-kidney-transplant-recipients
#4
Mara A McAdams-DeMarco, Sunjae Bae, Nadia Chu, Alden L Gross, Charles H Brown, Esther Oh, Paul Rosenberg, Karin J Neufeld, Ravi Varadhan, Marilyn Albert, Jeremy Walston, Dorry L Segev
Older patients with ESRD who receive a kidney transplant (KT) may develop post-KT dementia and Alzheimer's disease (AD) associated with their long-standing kidney disease and/or neurotoxic immunosuppressant agents. To investigate this possibility, we studied 40,918 older (aged ≥55 years) KT recipients (January 1, 1999 to December 31, 2011) linked to Medicare claims through the US Renal Data System. We estimated dementia and AD risk (cumulative incidence) and studied factors associated with these sequelae using competing risks models...
December 15, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27779800/the-expanded-criteria-donor-for-kidney-transplant-not-a-nearly-new-car
#5
Johan De Meester
No abstract text is available yet for this article.
January 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27472096/criteria-for-and-appropriateness-of-renal-transplantation-in-elderly-patients-with-end-stage-renal-disease-a-literature-review-and-position-statement-on-behalf-of-the-european-renal-association-european-dialysis-and-transplant-association-descartes-working
#6
Liviu Segall, Ionuţ Nistor, Julio Pascual, Istvan Mucsi, Lluis Guirado, Robert Higgins, Steven Van Laecke, Rainer Oberbauer, Wim Van Biesen, Daniel Abramowicz, Cristina Gavrilovici, Ken Farrington, Adrian Covic
During the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie ≥65 years of age) are still more rarely referred or accepted to waiting lists and, if enlisted, have less chances of actually receiving a kidney allograft, than younger counterparts. In this review, we looked at evidence for the benefits and risks of RT in the elderly trying to answer the following questions: Should RT be advocated for elderly patients? What should be the criteria to accept elderly patients on the waiting list for RT? What strategies might be used to increase the rate of RT in waitlisted elderly candidates? For selected elderly patients, RT was shown to be superior to dialysis in terms of patient survival...
October 2016: Transplantation
https://www.readbyqxmd.com/read/27729570/stretching-the-limits-of-renal-transplantation-in-elderly-recipients-of-grafts-from-elderly-deceased-donors
#7
Hessel Peters-Sengers, Stefan P Berger, Martin B A Heemskerk, Doaa Al Arashi, Jaap J Homan van der Heide, Aline C Hemke, Ineke J M Ten Berge, Mirza M Idu, Michiel G H Betjes, Arjan D van Zuilen, Luuk B Hilbrands, Aiko P J de Vries, Azam S Nurmohamed, Maarten H Christiaans, L W Ernest van Heurn, Johan W de Fijter, Frederike J Bemelman
An increasing number of elderly patients (≥65 years) receive a donor kidney from elderly donors after brain death (DBD) or after circulatory death (DCD). These organs are allocated within the Eurotransplant Senior Program, but outcomes must be evaluated. From the Dutch Organ Transplantation Registry, we selected 3597 recipients (≥18 years) who received a first DBD or DCD kidney during 2002-2012, and categorized them as young or elderly recipients receiving a graft from either a young or elderly donor, stratified by donor type...
February 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27172238/increasing-the-utilization-of-kidneys-from-unconventional-and-higher-risk-deceased-donors
#8
Raymond L Heilman, Amit Mathur, Maxwell L Smith, Bruce Kaplan, Kunam S Reddy
This review will concentrate on the literature regarding donor kidneys that are currently being utilized at a relatively low rate. Donors with AKI seem to have outcomes equivalent to those without AKI provided one can rule out significant cortical necrosis. Donors with pre-existing diabetes or hypertension may have a marginally lower aggregate survival, but still provide a significant benefit over remaining on the wait list. As KDPI only derives an aggregate association with survival with a very modest C statistic, the data would indicate that this should not be the sole reason to discard a kidney except perhaps in patients with extremely low EPTS scores...
May 12, 2016: American Journal of Transplantation
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