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Mopett trial

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By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/23624534/thrombolytic-therapy-for-submassive-pulmonary-embolus-pro-viewpoint
#1
EDITORIAL
Luke S Howard
No abstract text is available yet for this article.
February 2014: Thorax
https://www.readbyqxmd.com/read/23102885/moderate-pulmonary-embolism-treated-with-thrombolysis-from-the-mopett-trial
#2
RANDOMIZED CONTROLLED TRIAL
Mohsen Sharifi, Curt Bay, Laura Skrocki, Farnoosh Rahimi, Mahshid Mehdipour
The role of low-dose thrombolysis in the reduction of pulmonary artery pressure in moderate pulmonary embolism (PE) has not been investigated. Because the lungs are very sensitive to thrombolysis, we postulated that effective and safe thrombolysis might be achieved by a lower dose of tissue plasminogen activator. The purpose of the present study was to evaluate the role of this "safe dose" thrombolysis in the reduction of pulmonary artery pressure in moderate PE. During a 22-month period, 121 patients with moderate PE were randomized to receive a "safe dose" of tissue plasminogen activator plus anticoagulation (thrombolysis group [TG], n = 61 patients) or anticoagulation alone (control group [CG], n = 60)...
January 15, 2013: American Journal of Cardiology
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