Hyponatremia guidelines 2013

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Lung cancer, in particular small cell lung cancer (SCLC), is a very aggressive solid tumour with limited therapeutic options to date. The majority of patients present, at the time of diagnosis, with extensive disease patterns and reduced performance status. Hyponatraemia is a common finding in SCLC (25%) which can be assigned to a paraneoplastic syndrome termed syndrome of inappropriate ADH secretion (SIADH) in 60% of cases. Hyponatraemia may cause significant and even dramatic neurocognitive deficits, if not treated in an effective manner...

Hyponatremia is a serious, but often overlooked, electrolyte imbalance that has been independently associated with a wide range of deleterious changes involving many different body systems. Untreated acute hyponatremia can cause substantial morbidity and mortality as a result of osmotically induced cerebral edema, and excessively rapid correction of chronic hyponatremia can cause severe neurologic impairment and death as a result of osmotic demyelination. The diverse etiologies and comorbidities associated with hyponatremia pose substantial challenges in managing this disorder...