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By Jason Mann No BS pulmonary critical care fellow
Niall D Ferguson, Deborah J Cook, Gordon H Guyatt, Sangeeta Mehta, Lori Hand, Peggy Austin, Qi Zhou, Andrea Matte, Stephen D Walter, Francois Lamontagne, John T Granton, Yaseen M Arabi, Alejandro C Arroliga, Thomas E Stewart, Arthur S Slutsky, Maureen O Meade
BACKGROUND: Previous trials suggesting that high-frequency oscillatory ventilation (HFOV) reduced mortality among adults with the acute respiratory distress syndrome (ARDS) were limited by the use of outdated comparator ventilation strategies and small sample sizes. METHODS: In a multicenter, randomized, controlled trial conducted at 39 intensive care units in five countries, we randomly assigned adults with new-onset, moderate-to-severe ARDS to HFOV targeting lung recruitment or to a control ventilation strategy targeting lung recruitment with the use of low tidal volumes and high positive end-expiratory pressure...
February 28, 2013: New England Journal of Medicine
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