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Renal Recovery

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168 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29978569/one-and-three-year-outcomes-in-patients-treated-with-intermittent-hemodialysis-for-acute-kidney-injury-prospective-observational-multicenter-post-hoc-finnaki-study
#1
Maija Eskola, Suvi T Vaara, Anna-Maija Korhonen, Jukka Sauranen, Niina Koivuviita, Eero Honkanen, Ville Pettilä, Mikko Haapio
BACKGROUND: Studies reporting renal and overall survival after acute kidney injury (AKI) treated exclusively with intermittent modalities of renal replacement therapy (IRRT) are rare. This study focused on outcomes of AKI patients treated with IRRT both in intensive care units (ICUs) and non-ICU dialysis units. METHODS: This prospective observational study was carried on during a 5-month period in 17 ICUs and 17 non-ICUs. ICU and non-ICU patients (total n = 138; 65 ICU, 73 non-ICU) requiring RRT for AKI and chosen to receive IRRT were included...
July 6, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29948445/long-term-outcomes-in-acute-kidney-injury-patients-who-underwent-continuous-renal-replacement-therapy-a-single-center-experience
#2
Harin Rhee, Gum Sook Jang, Yeo Jin An, Miyeun Han, Inseong Park, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Sang Heon Song
INTRODUCTION: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is the most severe form of AKI associated with poor short- and long-term patient outcomes. The aim of this study was to evaluate the variables associated with long-term patient survival in our clinic. METHODS: This was a single-center retrospective study with AKI survivors who received CRRT from March 2011 to February 2015. During the study period, all consecutive AKI survivors who underwent CRRT were included...
June 11, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26418059/acute-kidney-improving-the-pathway-of-care-for-patients-and-across-healthcare
#3
REVIEW
Richard J Fluck
PURPOSE OF REVIEW: Acute kidney injury (AKI) is common, harmful and of global concern. There is a need to understand the pathway of the management of AKI in order to identify potential areas where care can be improved, for the individual and for healthcare systems. RECENT FINDINGS: There has been considerable focus on risk assessment and earlier detection using changes in serum creatinine. There is less understanding of optimal management, enhanced and long-term recovery, and education to support better care...
November 2015: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/26342047/kinetic-egfr-and-novel-aki-biomarkers-to-predict-renal-recovery
#4
Antoine Dewitte, Olivier Joannès-Boyau, Carole Sidobre, Catherine Fleureau, Marie-Lise Bats, Philippe Derache, Sébastien Leuillet, Jean Ripoche, Christian Combe, Alexandre Ouattara
BACKGROUND AND OBJECTIVES: Prompt recognition of severe renal impairment could improve the early management of critically ill patients. We compared the value of kinetic eGFR, plasma neutrophil gelatinase-associated lipocalin (NGAL), and urine tissue inhibitor of metalloproteinase-2 and urine insulin-like growth factor-binding protein 7 ([TIMP-2]*[IGFBP7]) in predicting short-term recovery from AKI and major adverse kidney events. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: During the 6-month study period, 245 patients were admitted to our intensive care unit...
November 6, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/25704519/-diagnosis-and-pathophysiology-of-acute-renal-failure-is-prevention-possible
#5
REVIEW
Julius J Schmidt, Gernot Beutel, Jan T Kielstein
Acute kidney injury (AKI) in critically ill patients is on a dramatic rise. The same holds true for community acquired AKI. Two main mechanisms are responsible for this increase: the rising prevalence of chronic kidney disease and the progress in diagnostic and therapeutic procedures pushing the limits of impossible. Several new biomarkers have not only helped to identify patients at risk for AKI and diagnosing AKI within hours after the insult, they also helped improve our pathophysiological understanding of AKI...
February 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25217269/defining-the-acute-kidney-injury-and-repair-transcriptome
#6
REVIEW
Sanjeev Kumar, Jing Liu, Andrew P McMahon
The mammalian kidney has an intrinsic ability to repair after significant injury. However, this process is inefficient: patients are at high risk for the loss of kidney function in later life. No therapy exists to treat established acute kidney injury (AKI) per se: strategies to promote endogenous repair processes and retard associated fibrosis are a high priority. Whole-organ gene expression profiling has been used to identify repair responses initiated with AKI, and factors that may promote the transition from AKI to chronic kidney disease...
July 2014: Seminars in Nephrology
https://www.readbyqxmd.com/read/29890946/non-recovery-from-dialysis-requiring-acute-kidney-injury-and-short-term-mortality-and-cardiovascular-risk-a-cohort-study
#7
Benjamin J Lee, Chi-Yuan Hsu, Rishi V Parikh, Thomas K Leong, Thida C Tan, Sophia Walia, Kathleen D Liu, Raymond K Hsu, Alan S Go
BACKGROUND: The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. It is unknown whether patients with incident ESRD due to dialysis-requiring acute kidney injury (AKI-D) are at higher short-term risk for death and CVD events, compared with incident ESRD patients without preceding AKI-D. Few studies have examined the impact of recovery from AKI-D on subsequent CVD risk...
June 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29889939/progress-in-prevention-and-treatment-of-acute-kidney-injury-moving-beyond-kidney-attack
#8
John A Kellum, Rinaldo Bellomo, Claudio Ronco
No abstract text is available yet for this article.
June 11, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29870535/long-term-survival-in-patients-with-septic-acute-kidney-injury-is-strongly-influenced-by-renal-recovery
#9
Marco Fiorentino, Fadi A Tohme, Shu Wang, Raghavan Murugan, Derek C Angus, John A Kellum
BACKGROUND: Several studies have shown that long-term survival after acute kidney injury (AKI) is reduced even if there is clinical recovery. However, we recently reported that in septic shock patients those that recover from AKI have survival similar to patients without AKI. Here, we studied a cohort with less severe sepsis to examine the effects of AKI on longer-term survival as a function of recovery by discharge. METHODS: We analyzed patients with community-acquired pneumonia from the Genetic and Inflammatory Markers of Sepsis (GenIMS) cohort...
2018: PloS One
https://www.readbyqxmd.com/read/21691057/outcomes-following-dialysis-for-acute-kidney-injury-among-different-stages-of-chronic-kidney-disease
#10
Po-Hung Lee, Vin-Cent Wu, Fu-Chang Hu, Chun-Fu Lai, Yung-Ming Chen, Tun-Jun Tsai, Kwan-Dun Wu
BACKGROUND: Information is limited regarding the outcomes of patients with preexisting chronic kidney disease (CKD) who develop dialysis-requiring acute kidney injury. METHODS: 131 adult patients with advanced CKD who received emergent hemodialysis from January to June in 2002 were recruited and monitored for all-cause mortality and end-stage renal disease until the end of 2007. RESULTS: Among patients investigated, 21 (16%) were successfully withdrawn from acute hemodialysis after an average of 8 sessions of dialysis therapy (range: 1-44)...
2011: American Journal of Nephrology
https://www.readbyqxmd.com/read/29852498/tubular-recovery-after-acute-kidney-injury
#11
Hadi Fattah, Volker Vallon
BACKGROUND: A significant portion of patients who are affected by acute kidney injury (AKI) do not fully recover due to largely unclear reasons. Restoration of tubular function has been proposed to be a prerequisite for glomerular filtration rate (GFR) recovery. SUMMARY: Proximal tubular cells dedifferentiate during the tubular injury phase, which is required for subsequent cell proliferation and replacement of lost epithelial cells. Experimental studies indicate that some cells fail to redifferentiate and continue to produce growth factors (e...
May 31, 2018: Nephron
https://www.readbyqxmd.com/read/29770263/evaluation-of-quantitative-and-qualitative-renal-outcome-following-nephron-sparing-surgery
#12
Gautam Ram Choudhary, Arup Kumar Mandal, Uttam Mete, Ravimohan Mavuduru, Anish Bhatacharia, Anupam Lal, Suresh Goyal
Purpose: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. Patients and Methods: Fifty-two patients of localized renal mass (≤7 cm) were included in the study. A contrast-enhanced computed tomography abdomen was performed for characterization of tumor...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29732637/estimated-glomerular-filtration-rate-s-time-to-nadir-after-robot-assisted-partial-nephrectomy-predictors-and-clinical-significance-on-renal-functional-recovery
#13
Glen Denmer Santok, Ali Abdel Raheem, Ki Don Chang, Lawrence Kim, Trenton G Lum, Mohamed Jayed Alenzi, Woong Kyu Han, Young Deuk Choi, Koon Ho Rha
OBJECTIVES: To investigate the impact of postoperative time to nadir of estimated glomerular filtration rate on renal functional changes after robot-assisted partial nephrectomy. METHODS: From 2006 to 2015, 287 patients with renal mass who underwent robot-assisted partial nephrectomy in a referral center were analyzed. The cohort was evaluated based on their time to develop nadir: group 1 (no nadir), group 2 (<48 h) and group 3 (≥48 h). The outcome measures were to evaluate the renal function recovery between groups, risk factors for development of nadir ≥48 h, as well as predictors of chronic kidney disease upstaging...
May 6, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29725637/cystatin-c-predicts-renal-recovery-earlier-than-creatinine-among-patients-with-acute-kidney-injury
#14
Kamel A Gharaibeh, Abdurrahman M Hamadah, Ziad M El-Zoghby, John C Lieske, Timothy S Larson, Nelson Leung
Introduction: Serum cystatin C increases earlier than creatinine during acute kidney injury. However, whether cystatin C decreases earlier during recovery is unknown. This retrospective study aimed to determine the temporal trend between creatinine and cystatin C in acute kidney injury. Methods: We identified hospitalized patients with nonoliguric acute kidney injury who had serial creatinine and cystatin C values measured between May 2015 and May 2016. Demographic and laboratory data, causes of acute kidney injury, and relevant comorbidity data were collected through chart review...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29725650/effect-of-frequent-dialysis-on-renal-recovery-results-from-the-acute-renal-failure-trial-network-study
#15
Anitha Vijayan, Rowena B Delos Santos, Tingting Li, Charles W Goss, Paul M Palevsky
Introduction: The optimal frequency of intermittent hemodialysis (IHD) in the treatment of acute kidney injury (AKI) remains unclear. Increasing the frequency of IHD, while offering the possible advantage of reduced ultrafiltration requirement and less hemodynamic instability per session, amplifies patient contact with an extracorporeal circuit with possible deleterious cardiovascular and immunological consequences. A recent study suggested that intensive renal replacement therapy (RRT) is associated with a decrease in urine output during AKI...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29597223/discontinuation-of-continuous-renal-replacement-therapy-and-dialysis-dependence
#16
Gregorio Romero-González, Anna Lorenzin, Mauro Neri, Fiorenza Ferrari, Alejandra Molano-Triviño, Alessandra Brendolan, Claudio Ronco
Renal replacement therapy (RRT) is a form of extracorporeal support for critical patients, especially for those with acute kidney injury. This therapy enables to gain adequate control over the great metabolic and fluids demand when kidneys are not able to do so; this condition is habitually present in patients who are admitted to intensive care units. However, it is also clear that these patients present a higher mortality rate and, in some cases, complications associated with the therapy. Therefore, it is fundamental to optimize and customize different aspects of RRT that range from the ideal timing including the modality and the dose until its suspension or ending...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29575280/renal-regeneration-after-acute-kidney-injury
#17
REVIEW
Silvia Coelho, Guadalupe Cabral, José António Lopes, António Jacinto
Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term...
March 25, 2018: Nephrology
https://www.readbyqxmd.com/read/29556514/determinant-factors-for-chronic-kidney-disease-after-partial-nephrectomy
#18
REVIEW
Oscar D Martín, Heilen Bravo, Marcos Arias, Diego Dallos, Yesica Quiroz, Luis G Medina, Giovanni E Cacciamani, Raul G Carlini
The objective of this review is to evaluate the factors that determine the development or deterioration of Chronic Kidney Disease (CKD) after partial nephrectomy (PN). When current literature is reviewed, it is found that factors that influence renal function after partial nephrectomy, are multifactorial. Those are divided into pre-surgical factors, such as hypertension, diabetes mellitus, urolithiasis, obesity, metabolic syndrome among others; intra-surgical factors, like the surgical technique used, the remaining healthy tissue, the experience of the surgeon, the time and type of ischemia among others...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29552953/extended-mortality-and-chronic-kidney-disease-after-septic-acute-kidney-injury
#19
Horng-Ruey Chua, Weng-Kin Wong, Venetia Huiling Ong, Dipika Agrawal, Anantharaman Vathsala, Hui-Ming Tay, Amartya Mukhopadhyay
PURPOSE: To evaluate 1-year mortality in patients with septic acute kidney injury (AKI) and to determine association between initial AKI recovery patterns ( reversal within 5 days, beyond 5 days but recovery, or nonrecovery) and chronic kidney disease (CKD) progression. METHODS: Prospective observational study, with retrospective evaluation of initial nonconsenters, of critically ill patients with septic AKI. RESULTS: We studied 207 patients (age, mean [SD]: 64 [16] years, 39% males), of which 56 (27%), 18 (9%), and 9 (4%) died in intensive care unit (ICU), post-ICU in hospital, and posthospitalization, respectively...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29535141/predictors-and-prognostic-value-of-worsening-renal-function-during-admission-in-hfpef-versus-hfref-data-from-the-korahf-korean-acute-heart-failure-registry
#20
Jeehoon Kang, Jin Joo Park, Young-Jin Cho, Il-Young Oh, Hyun-Ah Park, Sang Eun Lee, Min-Seok Kim, Hyun-Jai Cho, Hae-Young Lee, Jin Oh Choi, Kyung-Kuk Hwang, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
BACKGROUND: Worsening renal function (WRF) is associated with adverse outcomes in patients with heart failure. We investigated the predictors and prognostic value of WRF during admission, in patients with preserved ejection fraction (HFpEF) versus those with reduced ejection fraction (HFrEF). METHODS AND RESULTS: A total of 5625 patients were enrolled in the KorAHF (Korean Acute Heart Failure) registry. WRF was defined as an absolute increase in creatinine of ≥0...
March 13, 2018: Journal of the American Heart Association
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