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AKI on CKD

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125 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28291091/impact-of-acute-kidney-injury-in-patients-hospitalized-with-pneumonia
#1
Lakhmir S Chawla, Richard L Amdur, Charles Faselis, Ping Li, Paul L Kimmel, Carlos E Palant
OBJECTIVES: Pneumonia is a common cause of hospitalization and can be complicated by the development of acute kidney injury. Acute kidney injury is associated with major adverse kidney events (death, dialysis, and durable loss of renal function [chronic kidney disease]). Because pneumonia and acute kidney injury are in part mediated by inflammation, we hypothesized that when acute kidney injury complicates pneumonia, major adverse kidney events outcomes would be exacerbated. We sought to assess the frequency of major adverse kidney events after a hospitalization for either pneumonia, acute kidney injury, or the combination of both...
April 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28302078/early-serum-creatinine-accurately-predicts-acute-kidney-injury-post-cardiac-surgery
#2
Keren Grynberg, Kevan R Polkinghorne, Sharon Ford, Fiona Stenning, Thomas E Lew, Jonathan A Barrett, Shaun A Summers
BACKGROUND: Acute Kidney Injury (AKI) is a well recognized complication of cardiac surgery. It is associated with significant morbidity and mortality. The aims of our study are twofold; 1. To define the incidence of AKI post cardiac surgery. 2. To identify pre-morbid and operative risk factors for developing AKI and to determine if immediate post operative serum creatinine (IPOsCr) accurately predicts the development of AKI. METHODS: We prospectively studied 196 consecutive patients undergoing elective (on-pump) cardiac surgery...
March 16, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28249270/dialysis-requirement-and-long-term-major-adverse-cardiovascular-events-in-patients-with-chronic-kidney-disease-and-superimposed-acute-kidney-injury
#3
Bolanle A Omotoso, Faruk Turgut, Emaad M Abdel-Rahman, Wenjun Xin, Jennie Z Ma, Kenneth W Scully, Fatiu A Arogundade, Rasheed A Balogun
BACKGROUND: Chronic kidney disease (CKD) patients who experience superimposed acute kidney injury (AKI) have been shown to be at higher risk of long-term sequelae of AKI when compared to those who do not experience AKI. It remains unclear whether the need for temporary dialysis intervention following superimposed AKI in patients with CKD has any effect on the long-term major adverse cardiovascular events (MACE). This study examines the relationship between temporary dialysis therapy following AKI and long-term major cardiovascular events in patients with background CKD...
March 2, 2017: Nephron
https://www.readbyqxmd.com/read/28183419/acute-kidney-injury-in-patients-continued-on-renin-angiotensin-system-blockers-during-hospitalization
#4
Numan Alabdan, Elvira O Gosmanova, Nhu Quynh T Tran, Carrie S Oliphant, Hu Pan, Joyce E Broyles, Joanna Q Hudson
BACKGROUND: Acute kidney injury (AKI) is common in hospitalized patients and is associated with adverse outcomes. This study aimed to evaluate patient characteristics and interventions during hospitalization associated with the development of AKI in patients continued on renin-angiotensin system (RAS) blockers during hospitalization. METHODS: A retrospective study of 184 adult patients admitted between January 2012 and September 2014 and continued on RAS blockers was conducted...
February 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28128223/neutrophil-gelatinase-associated-lipocalin-ngal-fails-as-an-early-predictor-of-contrast-induced-nephropathy-in-chronic-kidney-disease-anti-ci-aki-study
#5
Werner Ribitsch, Gernot Schilcher, Franz Quehenberger, Stefan Pilz, Rupert H Portugaller, Martini Truschnig-Wilders, Robert Zweiker, Marianne Brodmann, Philipp Stiegler, Alexander R Rosenkranz, John W Pickering, Joerg H Horina
The aim of the study was to evaluate the diagnostic accuracy of urinary neutrophil gelatinase- associated lipocalin (uNGAL) in patients with chronic kidney disease (CKD) as an early biomarker for contrast induced acute kidney injury (CI-AKI) and to investigate whether patients with an uNGAL increase might benefit from an additional intravenous volume expansion with regard to CI-AKI-incidence. We performed a prospective randomized controlled trial in 617 CKD-patients undergoing intra-arterial angiography. Urinary NGAL was measured the day before and 4-6hrs after angiography...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114127/management-of-chronic-kidney-disease-patients-in-the-intensive-care-unit-mixing-acute-and-chronic-illness
#6
REVIEW
Silvia De Rosa, Sara Samoni, Gianluca Villa, Claudio Ronco
Patients with chronic kidney disease (CKD) are at high risk for developing critical illness and for admission to intensive care units (ICU). 'Critically ill CKD patients' frequently develop an acute worsening of renal function (i.e. acute-on-chronic, AoC) that contributes to long-term kidney dysfunction, potentially leading to end-stage kidney disease (ESKD). An integrated multidisciplinary effort is thus necessary to adequately manage the multi-organ damage of those kidney patients and contemporaneously reduce the progression of kidney dysfunction when they are critically ill...
2017: Blood Purification
https://www.readbyqxmd.com/read/28088181/acute-and-chronic-kidney-disease-in-elderly-patients-with-hip-fracture-prevalence-risk-factors-and-outcome-with-development-and-validation-of-a-risk-prediction-model-for-acute-kidney-injury
#7
Christine J Porter, Iain K Moppett, Irene Juurlink, Jessica Nightingale, Christopher G Moran, Mark A J Devonald
BACKGROUND: Hip fracture is a common injury in older people with a high rate of postoperative morbidity and mortality. This patient group is also at high risk of acute kidney injury (AKI) and chronic kidney disease (CKD), but little is known of the impact of kidney disease on outcome following hip fracture. METHODS: An observational cohort of consecutive patients with hip fracture in a large UK secondary care hospital. Predictive modelling of outcomes using development and validation datasets...
January 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28003286/prescription-of-renin-angiotensin-system-blockers-and-risk-of-acute-kidney-injury-a-population-based-cohort-study
#8
Kathryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaran, Laurie A Tomlinson
OBJECTIVE: To investigate whether there is an association between use of ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB) and risk of acute kidney injury (AKI). STUDY DESIGN: We conducted a new-user cohort study of the rate of AKI among users of common antihypertensives. SETTING: UK primary care practices contributing to the Clinical Practice Research Datalink (CPRD) eligible for linkage to hospital records data from the Hospital Episode Statistics (HES) database between April 1997 and March 2014...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27974318/a-perspective-on-chronic-kidney-disease-progression
#9
REVIEW
Jianyong Zhong, Hai-Chun Yang, Agnes B Fogo
Chronic kidney disease (CKD) will progress to end stage without treatment, but the decline of renal function may not be linear. Compared with glomerular filtration rate and proteinuria, new surrogate markers, such as kidney injury molecule-1, neutrophil gelatinase-associated protein, apolipoprotein A-IV, and soluble urokinase receptor, may allow potential intervention and treatment in the earlier stages of CKD, which could be useful for clinical trials. New omic-based technologies reveal potential new genomic and epigenomic mechanisms that appear different from those causing the initial disease...
March 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27169469/pathophysiology-and-clinical-work-up-of-acute-kidney-injury
#10
Mario Meola, Federico Nalesso, Ilaria Petrucci, Sara Samoni, Claudio Ronco
Acute kidney injury (AKI), also known in the past as acute renal failure, is a syndrome characterized by the rapid loss of kidney excretory function. It is usually diagnosed by the accumulation of end products of nitrogen metabolism (urea and creatinine) or decreased urine output or both. AKI is the clinical consequence of several disorders that acutely affect the kidney, causing electrolytes and acid-base imbalance, hyperhydration and loss of depurative function. AKI is common in critical care patients in whom it is often secondary to extrarenal events...
2016: Contributions to Nephrology
https://www.readbyqxmd.com/read/27861446/preoperative-renal-insufficiency-underreporting-and-association-with-readmission-and-major-postoperative-morbidity-in-an-academic-medical-center
#11
Jeanna D Blitz, Marny H Shoham, Yixin Fang, Venod Narine, Neeraj Mehta, Beamy S Sharma, Paul Shekane, Samir Kendale
BACKGROUND: Making a formal diagnosis of chronic kidney disease (CKD) in the preoperative setting may be challenging because of lack of longitudinal data. We explored the predictive value of a single reduced preoperative estimated glomerular filtration rate (eGFR) value on adverse patient outcomes in the first 30 days after elective surgery. We compared the rate of major postoperative adverse events, including 30-day readmission rate, hospital length of stay, infection, acute kidney injury (AKI), and myocardial infarction across patients with declining preoperative eGFR values...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27798198/radical-versus-partial-nephrectomy-chronic-kidney-disease-progression-and-mortality-in-us-veterans
#12
Elani Streja, Kamyar Kalantar-Zadeh, Miklos Z Molnar, Jaime Landman, Onyebuchi A Arah, Csaba P Kovesdy
BACKGROUND: Partial nephrectomy is considered the preferred care for localized kidney tumors and may yield better patient and kidney survival and similar oncological outcomes compared with radical nephrectomy. We sought to reexamine these hypotheses in a large nationally representative cohort of US veterans who underwent radical or partial nephrectomy. METHODS: We identified 7073 US veterans who had a partial or radical nephrectomy between 2004 and 2013. We collected data on estimated glomerular filtration rate (eGFR) prior to admission for nephrectomy surgery, immediately after surgery and 180 days postsurgery...
October 25, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27742616/chronic-kidney-disease-progression-and-cardiovascular-outcomes-following-cardiac-catheterization-a-population-controlled-study
#13
Jeremiah R Brown, Richard J Solomon, R Brooks Robey, Meg E Plomondon, Thomas M Maddox, Emily J Marshall, Elizabeth L Nichols, Michael E Matheny, Thomas T Tsai, John S Rumsfeld, Richard E Lee, Mark J Sarnak
BACKGROUND: Studies of kidney disease associated with cardiac catheterization typically rely on billing records rather than laboratory data. We examined the associations between percutaneous coronary interventions, acute kidney injury, and chronic kidney disease progression using comprehensive Veterans Affairs clinical and laboratory databases. METHODS AND RESULTS: Patients undergoing percutaneous coronary interventions between 2005 and 2010 (N=24 405) were identified in the Veterans Affairs Clinical Assessment, Reporting, and Tracking registry and examined for associated acute kidney injury and chronic kidney disease development or progression relative to 24 405 matched population controls...
October 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27719737/the-other-side-of-vitamin-d-therapy-%C3%A2-a-case-series-of-acute-kidney-injury-due-to-malpractice-related-vitamin-d-intoxication%C3%A2
#14
Muzafar Wani, Imtiaz Wani, Khurshid Banday, Mohd Ashraf
BACKGROUND: Vitamin D deficiency is highly prevalent in Indian Kashmir. Many people get injectable vitamin D (600,000 IU/injection). At times, the dose prescribed is far above the permissible limit. We report 62 patients with malpractice-related vitamin D intoxication, presenting with hypercalcemia and acute kidney injury (AKI). METHODS: The diagnosis was made on basis of (1) history of multiple intramuscular vitamin D injections (2) toxic serum levels of 25-OH vitamin D and (3) exclusion of common causes of hypercalcemia (malignancy and hyperparathyroidism)...
November 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27723839/remote-ischemic-preconditioning-for-the-prevention-of-contrast-induced-acute-kidney-injury-in-diabetics-receiving-elective-percutaneous-coronary-intervention
#15
Gillian Balbir Singh, Soe Hee Ann, Jongha Park, Hyun Chul Chung, Jong Soo Lee, Eun-Sook Kim, Jung Il Choi, Jiho Lee, Shin-Jae Kim, Eun-Seok Shin
OBJECTIVE: Remote ischemic preconditioning (RIPC) induces transient episodes of ischemia by the occlusion of blood flow in non-target tissue, before a subsequent ischemia-reperfusion injury. When RIPC is applied before percutaneous coronary intervention (PCI), the kidneys may be protected against ischemia-reperfusion injury and subsequently contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the efficacy of RIPC for the prevention of CI-AKI in patients with diabetes with pre-existing chronic kidney disease (CKD) undergoing elective PCI...
2016: PloS One
https://www.readbyqxmd.com/read/27704535/the-association-between-pre-operative-variables-including-blood-pressure-and-postoperative-kidney-function
#16
S M Kendale, P N Lapis, S M Melhem, J D Blitz
We used multivariate analyses to assess the association of pre-operative variables with kidney function in 41,523 adults after scheduled surgery in a single large academic hospital. Eight variables were independently associated with a reduction in postoperative estimated glomerular filtration rate: pre-operative renal function; age; ASA physical status; cardiac failure; anaemia; cancer; type of surgery; and the lowest quartile of pre-operative mean arterial blood pressure (< 71 mmHg). The estimated glomerular filtration rate fell by a mean (95% CI) of 2...
December 2016: Anaesthesia
https://www.readbyqxmd.com/read/27684854/a-nationwide-survey-of-clinical-characteristics-management-and-outcomes-of-acute-kidney-injury-aki-patients-with-and-without-preexisting-chronic-kidney-disease-have-different-prognoses
#17
MULTICENTER STUDY
Heng-Chih Pan, Pei-Chen Wu, Vin-Cent Wu, Ya-Fei Yang, Tao-Min Huang, Chih-Chung Shiao, Te-Chuan Chen, Der-Cherng Tarng, Jui-Hsiang Lin, Wei-Shun Yang, Chiao-Yin Sun, Chan-Yu Lin, Tzong-Shinn Chu, Mai-Szu Wu, Kwan-Dun Wu, Yung-Chang Chen, Chiu-Ching Huang
Acute kidney injury (AKI) is a common complication in hospitalized patients. The International Society of Nephrology implemented the "0 by 25" initiative aimed at preventing deaths from treatable AKI worldwide by 2025 and conducted a global snapshot survey in 2014. We joined in the project and conducted this study to compare the epidemiology, risk factors, and prognosis between patients with pure AKI and those with acute-on-chronic kidney disease (ACKD). In this study, we prospectively collected demographic parameters and data on clinical characteristics, baseline comorbidities, management, and outcomes of 201 AKI patients in 18 hospitals in Taiwan from September 2014 to November 2014...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27673681/acute-kidney-injury-treated-with-dialysis-outside-the-intensive-care-unit-a-retrospective-observational-single-center-study
#18
Hannelore Sprenger-Mähr, Emanuel Zitt, Karl Lhotta
INTRODUCTION: The number of patients suffering from acute kidney injury requiring dialysis (AKI-D) is increasing. Whereas causes and outcome of AKI-D in the intensive care unit (ICU) are described extensively, few data exist about AKI-D patients treated outside the ICU. Aim of this study was to identify the causes of AKI-D, determine in-depth the comorbid conditions and outcome of this particular patient group and identify possibilities for its prevention. METHODS: We retrospectively studied all AKI-D patients treated outside the ICU in a single nephrology referral center between January 2010 and June 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27627622/short-term-and-long-term-effects-of-acute-kidney-injury-in-chronic-kidney-disease-patients-a-longitudinal-analysis
#19
Özgür Asar, James Ritchie, Philip A Kalra, Peter J Diggle
We use data from an ongoing cohort study of chronic kidney patients at Salford Royal NHS Foundation Trust, Greater Manchester, United Kingdom, to investigate the influence of acute kidney injury (AKI) on the subsequent rate of change of kidney function amongst patients already diagnosed with chronic kidney disease (CKD). We use a linear mixed effects modelling framework to enable estimation of both acute and chronic effects of AKI events on kidney function. We model the fixed effects by a piece-wise linear function with three change-points to capture the acute changes in kidney function that characterise an AKI event, and the random effects by the sum of three components: a random intercept, a stationary stochastic process with Matérn correlation structure, and measurement error...
September 14, 2016: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/27636535/renal-dysfunction-and-transcatheter-aortic-valve-implantation-outcomes
#20
REVIEW
Marco Barbanti, Giuseppe Gargiulo, Corrado Tamburino
Transcatheter aortic valve implantation (TAVI) underwent progressive improvements until it became the default therapy for inoperable patients, and a recommended therapy in high-risk operable patients with symptomatic severe aortic stenosis. Recent evidence will further support TAVI as treatment for a growing number of patients. Areas covered: This review will discuss on the current knowledge about the role of both pre-procedural chronic kidney disease (CKD) and post-procedural acute kidney injury (AKI) in adult patients with severe aortic stenosis undergoing TAVI...
December 2016: Expert Review of Cardiovascular Therapy
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