Frederick D'Aragon, Emilie P Belley-Cote, Maureen O Meade, François Lauzier, Neill K J Adhikari, Matthias Briel, Manoj Lalu, Salmaan Kanji, Pierre Asfar, Alexis F Turgeon, Alison Fox-Robichaud, John C Marshall, François Lamontagne
Physicians often prescribe vasopressors to correct pathological vasodilation and improve tissue perfusion in patients with septic shock, but the evidence to inform practice on vasopressor dosing is weak. We undertook a systematic review of clinical studies evaluating different blood pressure targets for the dosing of vasopressors in septic shock. We searched MEDLINE, EMBASE, CENTRAL (to November 2013), reference lists from included articles, and trial registries for randomized controlled trials (RCTs) and observational and crossover intervention studies comparing different blood pressure targets for vasopressor therapy in septic shock...
June 2015: Shock