Beatriz Maria Veloso Pereira, Yuting Zeng, Joseph C Maggiore, Robert Allen Schweickart, Diana G Eng, Natalya Kaverina, Sierra R McKinzie, Anthony Chang, Carol J Loretz, Karina Thieme, Neil A Hukriede, Jeffrey W Pippin, Oliver Wessely, Stuart J Shankland
As life expectancy continues to rise, age-related diseases are becoming more prevalent. For example, proteinuric glomerular diseases typified by podocyte injury have worse outcomes in the elderly compared to young patients. However, the reasons are not well understood. We hypothesized that injury to non-aged podocytes induces senescence, which in turn augments their aging processes. In primary cultured human podocytes, injury induced by a cytopathic anti-podocyte antibody, Adriamycin, or Puromycin Aminonucleoside increased the senescence-related genes CDKN2A (p16INK4a/p14ARF), CDKN2D (p19INK4d), and CDKN1A (p21)...
October 19, 2023: American Journal of Physiology. Renal Physiology