Louise Bowman, Marion Mafham, Karl Wallendszus, Will Stevens, Georgina Buck, Jill Barton, Kevin Murphy, Theingi Aung, Richard Haynes, Jolyon Cox, Aleksandra Murawska, Allen Young, Michael Lay, Fang Chen, Emily Sammons, Emma Waters, Amanda Adler, Jonathan Bodansky, Andrew Farmer, Roger McPherson, Andrew Neil, David Simpson, Richard Peto, Colin Baigent, Rory Collins, Sarah Parish, Jane Armitage
BACKGROUND: Increased intake of n-3 fatty acids has been associated with a reduced risk of cardiovascular disease in observational studies, but this finding has not been confirmed in randomized trials. It remains unclear whether n-3 (also called omega-3) fatty acid supplementation has cardiovascular benefit in patients with diabetes mellitus. METHODS: We randomly assigned 15,480 patients with diabetes but without evidence of atherosclerotic cardiovascular disease to receive 1-g capsules containing either n-3 fatty acids (fatty acid group) or matching placebo (olive oil) daily...
October 18, 2018: New England Journal of Medicine