M Taniguchi, L M Rebellato, J Cai, J Hopfield, K P Briley, C E Haisch, P G Catrou, P Bolin, K Parker, W T Kendrick, S A Kendrick, R C Harland, P I Terasaki
Reports have associated non-HLA antibodies, specifically those against angiotensin II type-1 receptor (AT1R), with antibody-mediated kidney graft rejection. However, association of anti-AT1R with graft failure had not been demonstrated. We tested anti-AT1R and donor-specific HLA antibodies (DSA) in pre- and posttransplant sera from 351 consecutive kidney recipients: 134 with biopsy-proven rejection and/or lesions (abnormal biopsy group [ABG]) and 217 control group (CG) patients. The ABG's rate of anti-AT1R was significantly higher than the CG's (18% vs...
October 2013: American Journal of Transplantation