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Autophagy Regulation

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2 papers 0 to 25 followers
By Lazaro Garcia flores Neuroendocrino tumor
Patricia Boya, Fulvio Reggiori, Patrice Codogno
Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead...
July 2013: Nature Cell Biology
Anne Hamacher-Brady
SIGNIFICANCE: Study over the past decade has revealed the critical role of autophagy in homeostatic and stress cell signaling. Autophagy is an intracellular process whereby double-membrane structures termed autophagosomes deliver cellular components to lysosomes for their degradation. RECENT ADVANCES: Targets of specific autophagy range from proteins to protein aggregates to organelles and intracellular pathogens. Accordingly, autophagy fulfills numerous physiological roles and its deregulation can underlie disease...
September 1, 2012: Antioxidants & Redox Signaling
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