John P Bilezikian, Maria Luisa Brandi, Natalie E Cusano, Michael Mannstadt, Lars Rejnmark, René Rizzoli, Mishaela R Rubin, Karen K Winer, Uri A Liberman, John T Potts
CONTEXT: Conventional management of hypoparathyroidism has focused upon maintaining the serum calcium with oral calcium and active vitamin D, often requiring high doses and giving rise to concerns about long-term consequences including renal and brain calcifications. Replacement therapy with PTH has recently become available. This paper summarizes the results of the findings and recommendations of the Working Group on Management of Hypoparathyroidism. EVIDENCE ACQUISITION: Contributing authors reviewed the literature regarding physiology, pathophysiology, and nutritional aspects of hypoparathyroidism, management of acute hypocalcemia, clinical aspects of chronic management, and replacement therapy of hypoparathyroidism with PTH peptides...
June 2016: Journal of Clinical Endocrinology and Metabolism