Valeria Grancini, Maddalena Trombetta, Maria Elena Lunati, Dario Zimbalatti, Maria Linda Boselli, Stefano Gatti, Maria Francesca Donato, Veronica Resi, Roberta D'Ambrosio, Alessio Aghemo, Giuseppe Pugliese, Riccardo C Bonadonna, Emanuela Orsi
BACKGROUND & AIMS: This study evaluated the contribution of β-cell dysfunction and insulin resistance to cirrhosis-associated diabetes. METHODS: One-hundred and sixty cirrhotic patients with normal fasting plasma glucose (FPG), three with impaired fasting glucose and seven with untreated diabetes mellitus (DM) underwent an extended oral glucose tolerance test (OGTT). The OGTT data were analyzed with a Minimal Model to estimate dynamic (derivative) control (DC) and static (proportional) control (PC) of β-cell function, and with the Oral Glucose Insulin Sensitivity (OGIS)-2h index to estimate insulin sensitivity...
December 2015: Journal of Hepatology