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Vascular endothelial cadherin is expressed by perineurial cells of peripheral nerve.
Histopathology 1998 May
AIMS: To study the distribution of vascular endothelial (VE) cadherin in peripheral nerves.
METHODS AND RESULTS: Using two monoclonal antibodies that detect VE-cadherin (TEA1.31 and 7B4) an immunohistochemical study of VE-cadherin expression in five common peroneal nerve biopsies and five skin specimens containing small peripheal nerves was performed. VE-cadherin was consistently expressed by the perineurium of nerves but not by other nerve elements such as Schwann cells or axons.
CONCLUSION: This report indicates that VE-cadherin is not. as was previously thought, a specific marker of endothelial cells and further defines the phenotype of the perineurial cell. The established role of VE-cadherin in controlling the permeability of vascular endothelium suggests that this molecule may have a similar role in the perineurium. VE-cadherin may therefore be important in the maintenance of the blood-nerve barrier, the peripheral nerve equivalent of the blood-brain barrier.
METHODS AND RESULTS: Using two monoclonal antibodies that detect VE-cadherin (TEA1.31 and 7B4) an immunohistochemical study of VE-cadherin expression in five common peroneal nerve biopsies and five skin specimens containing small peripheal nerves was performed. VE-cadherin was consistently expressed by the perineurium of nerves but not by other nerve elements such as Schwann cells or axons.
CONCLUSION: This report indicates that VE-cadherin is not. as was previously thought, a specific marker of endothelial cells and further defines the phenotype of the perineurial cell. The established role of VE-cadherin in controlling the permeability of vascular endothelium suggests that this molecule may have a similar role in the perineurium. VE-cadherin may therefore be important in the maintenance of the blood-nerve barrier, the peripheral nerve equivalent of the blood-brain barrier.
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