We have located links that may give you full text access.
CLINICAL TRIAL
COMPARATIVE STUDY
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
RESEARCH SUPPORT, NON-U.S. GOV'T
The effect of morphine and naloxone administration on maternal oxytocin concentration in late pregnancy.
Clinical Endocrinology 1993 December
OBJECTIVE: Modification of the inhibitory control of oxytocin secretion by endogenous opiates in late pregnancy may be one of the factors involved in the onset of labour. The interrelationships between exogenously administered opioids and oxytocin may demonstrate activity of this control mechanism. This study was undertaken to investigate the effect of an opiate and an opiate antagonist on maternal oxytocin levels in late pregnancy.
DESIGN: Patients were randomized to receive either morphine (5 mg), naloxone (2.4 mg) or sterile water (1 ml) intravenously.
PATIENTS: Thirty women with singleton pregnancies greater than 36 weeks gestation who were not in labour were studied.
MEASUREMENTS: Blood for peripheral oxytocin levels was sampled every 2.5 minutes for 15 minutes before and 15 minutes after administration of the assigned substance. Oxytoxin was measured by radioimmunoassay. Peripheral beta-endorphin levels were measured at the beginning and end of the study.
RESULTS: There was no significant change in the maternal oxytocin concentration after administration of either morphine, naloxone or sterile water compared to pretreatment levels. beta-Endorphin levels did not change significantly, either from the beginning to the end of the study, or between groups.
CONCLUSION: In late pregnancy exogenous opiates and opiate antagonists have no effect on maternal peripheral oxytocin levels.
DESIGN: Patients were randomized to receive either morphine (5 mg), naloxone (2.4 mg) or sterile water (1 ml) intravenously.
PATIENTS: Thirty women with singleton pregnancies greater than 36 weeks gestation who were not in labour were studied.
MEASUREMENTS: Blood for peripheral oxytocin levels was sampled every 2.5 minutes for 15 minutes before and 15 minutes after administration of the assigned substance. Oxytoxin was measured by radioimmunoassay. Peripheral beta-endorphin levels were measured at the beginning and end of the study.
RESULTS: There was no significant change in the maternal oxytocin concentration after administration of either morphine, naloxone or sterile water compared to pretreatment levels. beta-Endorphin levels did not change significantly, either from the beginning to the end of the study, or between groups.
CONCLUSION: In late pregnancy exogenous opiates and opiate antagonists have no effect on maternal peripheral oxytocin levels.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app