We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Rapid and sustained rise in the serum level of hyaluronan after anterior cruciate ligament transection in the dog knee joint.
Journal of Rheumatology 1995 Februrary
OBJECTIVE: To monitor changes in serum levels of hyaluronan (HA) in experimental canine osteoarthritis (OA), and to relate these changes to the level of HA in synovial fluid (SF) and/or to the rate of HA synthesis by synovium.
METHODS: OA was induced in 16 dogs by anterior cruciate ligament transection; 7 dogs were sham operated. An immunoassay was used to measure HA levels in serum at various times postsurgery and in SF from OA knees at sacrifice (Week 13 postsurgery). The rate of HA synthesis by synovium from both knees of 9 OA dogs and 5 sham operated dogs was measured at 13 weeks.
RESULTS: The serum level of HA showed a minor transient rise postsurgery in sham operated dogs. In all OA dogs, this rise was marked and sustained and correlated with the SF level of HA. Further, in OA dogs, the rate of HA synthesis by synovium was elevated in both the operated OA knee and the nonoperated knee.
CONCLUSION: The sustained rise in the serum level of HA in OA dogs appears to be the result of increases in the rate of HA synthesis by synovium in both the operated and nonoperated knees, and possibly in other synovial joints.
METHODS: OA was induced in 16 dogs by anterior cruciate ligament transection; 7 dogs were sham operated. An immunoassay was used to measure HA levels in serum at various times postsurgery and in SF from OA knees at sacrifice (Week 13 postsurgery). The rate of HA synthesis by synovium from both knees of 9 OA dogs and 5 sham operated dogs was measured at 13 weeks.
RESULTS: The serum level of HA showed a minor transient rise postsurgery in sham operated dogs. In all OA dogs, this rise was marked and sustained and correlated with the SF level of HA. Further, in OA dogs, the rate of HA synthesis by synovium was elevated in both the operated OA knee and the nonoperated knee.
CONCLUSION: The sustained rise in the serum level of HA in OA dogs appears to be the result of increases in the rate of HA synthesis by synovium in both the operated and nonoperated knees, and possibly in other synovial joints.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app