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CASE REPORTS
ENGLISH ABSTRACT
JOURNAL ARTICLE
[Familial lymphohistiocytosis. Anatomopathological study of 2 cases detected neonatally].
Archives Françaises de Pédiatrie 1982 October
Two brothers presented with hemophagocytic reticulosis with neonatal onset. Early clinical and biological symptoms included pallor, hepatosplenomegaly and anemia, thrombocytopenia. Evolution was lethal in both cases, at 5 months and 13 days of age, respectively. Diagnosis was confirmed in both by the pathologic findings: diffuse lymphohistiocytic cellular proliferation with hemophagocytosis and atrophy of the lymphoid tissue. The diagnostic difficulties of this disease in the neonatal period are emphasized.
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