[Cytoarchitectonics and intercellular relations during posttraumatic regeneration of the epidermis].

Dynamics of changes of intercellular contacts in the mouse spine epidermis have been studied in 1, 3, 5, 7, 10 days after its traumatic lesion performed up to the upper level of the papillary layer of the derm. In one day a complete desintegration of basal keratinocytes with some signs of reactive changes takes place. A partial desintegration is noted in the exfoliated spinous layer, which participates in the crust formation, as well as in formation of cells in marginal zones of the defect. When there is an intercellular edema, desmosomes manifest themselves as the most highly-adhesive junctions. On the 1st-7th day melanocytes loose their contacts with keratinocytes, but do not display any reactive changes. On the 7th day hyperplasia of the epithelial layer is noted with an increased number of apigmented granular dendrocytes that participate in fagocytosis. The intercellular contacts are reconstructed, however, essential intercellular spaces remain. By the 10th day the contacting surfaces of the cells are completely formed, possessing all specific for epidermis specialized junctions. Columnar organization of the layer is formed.