Marihuana: standardized smoke administration and dose effect curves on heart rate in humans.

P F Renault, C R Schuster, R Heinrich, D X Freeman

Science 1971 November 6

A spirometer was used to deliver marihuana and placebo smoke to human subjects. This procedure produced linear dose-effect curves on heart rate and replicable dose effects in individual subjects. No differences were observed between experienced and inexperienced smokers in responsiveness to heart rate increases produced by marihuana.

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