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Palladium-Catalyzed Weak Chelation-Assisted Site-Selective C-H Arylation of N -Aryl Pyridones via 2-fold C-H Activation.
Journal of Organic Chemistry 2024 April 18
Palladium-catalyzed weak chelation-assisted oxidative cross-dehydrogenative coupling of arenes has been accomplished. The use of medicinally important pyridones as the intrinsic directing group, regioselectivity, 2-fold C-H activation, and late-stage modification of bioactive compounds are the important practical features.
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