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Total Synthesis of the Diterpenes (+)-Randainin D and (+)-Barekoxide via Photoredox-Catalyzed Deoxygenative Allylation.
Journal of the American Chemical Society 2024 April 16
We report the first enantioselective total synthesis of diterpenoid randainin D, which possesses a hydroazulenone core with a β-substituted butenolide moiety on the cycloheptane ring. The trans -5/7 ring system was formed via a highly challenging ring-closing metathesis delivering the tetrasubstituted cycloheptenone. The butenolide moiety was installed via a novel deoxygenative allylation under Ir-photoredox catalysis, employing methyl oxalate as a red/ox tag. Moreover, the developed allylation was successfully utilized in the 7-step total synthesis of (+)-barekoxide. This study suggests that this deoxygenative allylation method is a promising strategy for the formation of Cq-C(sp3 ) bonds (Cq = quaternary center) in the context of natural product synthesis.
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