Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.

Resecting cortical tissue generating high-frequency oscillations (HFOs) has been investigated as a more efficacious alternative to resecting the clinically defined seizure onset zone (SOZ). In this study, we asked if seizure freedom would be achieved using virtual resections of fast ripple (FR) networks. We compared these virtual resections to the individual patient's actual resection and clinical outcome. We conclude that the SOZ is the minimum territory of cortex that must be resected to achieve seizure freedom. By utilizing support vector machines (SVMs) with an accuracy of 0.78 for labeling seizure freedom using factors from FR networks we could predict whether resection of the SOZ corresponded with a seizure free outcome. Furthermore, this approach could identify regions that generate FR autonomously and at high rates outside the SOZ. In the patients who experienced seizures after resection of the SOZ, virtual resections that included the SOZ and other FR generating regions rendered the patient virtually seizure free. We examined responsive neurostimulator system (RNS) patients and virtually targeted the RNS stimulation contacts proximal to sites generating FR. We used the simulations to investigate if the likelihood of a RNS super responder (>90% seizure reduction) outcome would be increased.