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Intraoperative Fluorescence Guidance for Breast Cancer Lumpectomy Surgery.

Barbara L Smith, Kelly K Hunt, David Carr, Peter W Blumencranz, E Shelley Hwang, Michele A Gadd, Kimberly Stone, Donna L Dyess, Daleela Dodge, Stephanie Valente, Nayana Dekhne, Patricia Clark, Marie Catherine Lee, Laila Samiian, Beth-Anne Lesnikoski, Lynne Clark, Kate Porta Smith, Manna Chang, Daniel K Harris, Brian Schlossberg, Jorge Ferrer, Irene L Wapnir
NEJM Evid 2023 July
Fluorescence Guidance for Lumpectomy SurgeryThis prospective trial of 406 patients assessed margin status with and without pegulicianine fluorescence-guided surgery (pFGS) for stages 0 to 3 breast cancers. The use of pFGS met prespecified thresholds for removal of residual tumor and specificity but did not meet the prespecified threshold for sensitivity.

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