Insulin Dysregulated Horses Metabolic Responses to Forage Pellets.

Hyperinsulinemia-associated laminitis (HAL) is the primary concern for insulin dysregulated (ID) equids and their insulin response to the consumption of oral, nonstructural carbohydrates (NSC) has been shown to be a risk predictor for HAL development. This randomized, crossover study's objective was to examine the insulinemic responses to 3 forage pellets (1 g/kg BW) (timothy hay, TH, 9.5% CP & 10% NSC DM; alfalfa hay, AH, 16.3% CP & 9.8% NSC DM; timothy-alfalfa hay; TAH, 17.2% CP & 9.8% NSC DM) along with a positive (dehulled oats; OG, 14.7% CP & 59.7% NSC DM) and negative dietary challenge control (low-NSC; LNSC, 12.8% CP & 5.4% NSC DM) of ID (n=8; 16.1 ± 2.2 yr; 565.4 ± 99.1 kgs.) and non-ID (NID; n=7; 17.0 ± 2.8 yr; 583.6 ± 57.9 kgs.) horses. ID horses had higher positive incremental area under the curve for insulin (IAUCi) (ID: 890 ± 925 µIU/mL*minute vs. NID: 225 ± 228 µIU/mL*minute), peak (ID: 101.5 ± 80.72 µIU/mL vs. NID: 25.7 ± 7.2 µIU/mL), and delta (ID: 45.5 ± 77.1 µIU/mL vs. NID: 4.9 ± 5.3 µIU/mL) insulin for all forage pellets compared to NID (p<0.01). ID horses IAUCi for the forage pellets was not different compared to the LNSC (218 ± 327 µIU/mL*minute) but was different from OG (10,522 ± 4,565 µIU/mL*minute). ID horses' lack of an augmented insulinemic response to the low NSC forage pellets (fed in small amounts) indicates that they could be a safe feedstuff for ID animals.