Graph- and transformer-guided boundary aware network for medical image segmentation.

BACKGROUND AND OBJECTIVE: Despite the considerable progress achieved by U-Net-based models, medical image segmentation remains a challenging task due to complex backgrounds, irrelevant noises, and ambiguous boundaries. In this study, we present a novel approach called U-shaped Graph- and Transformer-guided Boundary Aware Network (GTBA-Net) to tackle these challenges.

METHODS: GTBA-Net uses the pre-trained ResNet34 as its basic structure, and involves Global Feature Aggregation (GFA) modules for target localization, Graph-based Dynamic Feature Fusion (GDFF) modules for effective noise suppression, and Uncertainty-based Boundary Refinement (UBR) modules for accurate delineation of ambiguous boundaries. The GFA modules employ an efficient self-attention mechanism to facilitate coarse target localization amidst complex backgrounds, without introducing additional computational complexity. The GDFF modules leverage graph attention mechanism to aggregate information hidden among high- and low-level features, effectively suppressing target-irrelevant noises while preserving valuable spatial details. The UBR modules introduce an uncertainty quantification strategy and auxiliary loss to guide the model's focus towards target regions and uncertain "ridges", gradually mitigating boundary uncertainty and ultimately achieving accurate boundary delineation.

RESULTS: Comparative experiments on five datasets encompassing diverse modalities (including X-ray, CT, endoscopic procedures, and ultrasound) demonstrate that the proposed GTBA-Net outperforms existing methods in various challenging scenarios. Subsequent ablation studies further demonstrate the efficacy of the GFA, GDFF, and UBR modules in target localization, noise suppression, and ambiguous boundary delineation, respectively.

CONCLUSIONS: GTBA-Net exhibits substantial potential for extensive application in the field of medical image segmentation, particularly in scenarios involving complex backgrounds, target-irrelevant noises, or ambiguous boundaries.