We have located links that may give you full text access.
CD248 Regulates Inflammation and Encapsulation in Silicone-related Capsule Formation.
Plastic and Reconstructive Surgery 2023 March 29
BACKGROUND: Capsular contracture is the most common reason for having a secondary breast implant surgery. The failure of the implanted device and discomfort are related to foreign body response, which involves a pathologic encapsulation. An upregulated expression of CD248 was previously demonstrated to modulate inflammation and fibrosis. We hypothesized that CD248 contributes to foreign body reaction and contracture during silicone-stimulated capsule formation.
METHODS: A murine capsular contracture model was established to correlate CD248 with capsular contracture. The timing and site of CD248 expression were characterized by protein analysis and histologic examination. The capsules between wild-type mice and CD248 knockout mice were compared in this model to verify the possible role of CD248 in silicone-related capsule formation.
RESULTS: CD248 was expressed in the peri-silicone implant capsule by stromal fibroblast and perivascular fibroblast. CD248 was overexpressed since day 4 and down to a constant level, but it was still upregulated through day 21 to day 56 after silicone implantation. The CD248 knockout mice showed a prolonged inflammation period, while the wild-type mice developed a thinner but more collagenous capsule.
CONCLUSIONS: In conclusion, an effective murine capsular contracture model was established to study the relationship between CD248 and capsular contracture. CD248 may play a role in inflammation and encapsulation during silicone implantation. CD248 deletion in mice contributed to a loose and irregular collagen bundle in a capsule area, implying a decrease in contracture. Therefore, CD248 could be a potential therapeutic target in capsular contracture.
METHODS: A murine capsular contracture model was established to correlate CD248 with capsular contracture. The timing and site of CD248 expression were characterized by protein analysis and histologic examination. The capsules between wild-type mice and CD248 knockout mice were compared in this model to verify the possible role of CD248 in silicone-related capsule formation.
RESULTS: CD248 was expressed in the peri-silicone implant capsule by stromal fibroblast and perivascular fibroblast. CD248 was overexpressed since day 4 and down to a constant level, but it was still upregulated through day 21 to day 56 after silicone implantation. The CD248 knockout mice showed a prolonged inflammation period, while the wild-type mice developed a thinner but more collagenous capsule.
CONCLUSIONS: In conclusion, an effective murine capsular contracture model was established to study the relationship between CD248 and capsular contracture. CD248 may play a role in inflammation and encapsulation during silicone implantation. CD248 deletion in mice contributed to a loose and irregular collagen bundle in a capsule area, implying a decrease in contracture. Therefore, CD248 could be a potential therapeutic target in capsular contracture.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app