Development and Validation of the Random Forest Model via Combining CT-PET Image Features and Demographic Data for Distant Metastases among Lung Cancer Patients.

The work aimed at developing and validating a random forest model of CT-PET image features combined with demographic data to diagnose distant metastases among lung cancer patients. This study involved lung cancer patients from The Cancer Genome Atlas lung adenocarcinoma (TCGA-LUAD) dataset, the lung PET-CT dataset, the lung squamous cell carcinoma (LSCC) dataset, and the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium lung adenocarcinoma (CPTAC-LUAD) dataset and collected the information on 178 CT, 178 PET, and the patients' age, history of smoking, and gender. We conducted image processing and feature extraction. Finally, 4 computed tomography (CT) image features and 2 positron emission tomography (PET) image features were extracted. Four prediction models based on CT image features, PET image features, and demographic data were developed, and the area under the receiver operating characteristic (ROC) curve was used to evaluate the performance of prediction models. A total of 178 eligible samples were randomly divided into a training set ( n  = 134) and a testing set ( n  = 44) at a ratio of 3 : 1, with 2021 as a random number. ROC analyses illustrated that the predictive performance for distant metastases of combining CT-PET image features and demographic data for training and testing were 0.923 (95% confidence interval (CI): 0.873-0.973) and 0.873 (95% CI: 0.757-0.990). In addition, the predictive performance of the combined model in the testing set was significantly better than that of the CT-demographic data model (0.716, 95% CI: 0.531-0.902), PET-demographic data model (0.802, 95% CI: 0.633-0.970), and CT-PET model (0.797, 95% CI: 0.666-0.928). The random forest model via combining CT-PET image features and demographic data could have great performance in predicting distant metastases among lung cancer patients.