PROGNOSTICATION OF COMPLICATED COURSE OF ACUTE MYOCARDIAL INFARCTION WITH CONCOMITANT TYPE 2 DIABETES MELLITUS BASED ON USE OF ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE-ІІ.

OBJECTIVE: The aim: To determine the prognostic value of endothelial monocytic peptide ІІ in the course of AMI (acute myocardial infarction) in combination with type 2 diabetes mellitus (DM).

PATIENTS AND METHODS: Materials and methods: The study involved 120 patients divided in 2 groups: Group 1 - patients with acute myocardial infarction (AMI) with concomitant type 2 DM (n=69); Group 2 - patients with AMI without concomitant type 2 DM (n=51). Control group was composed with 20 almost healthy persons.

RESULTS: Results: It was determined that in patients with AMI in combination with type 2 diabetes, the level of endothelial monocyte-activating polypeptide II (EMAP-II) was 1.65 times higher than in patients without concomitant type 2 DM (p <0.05). The patients with AMI and type 2 DM who were included in the group of the 3rd tertile according to level of EMAR-II had the complicated course compared to patients in the groups of the 1st and 2nd tertiles. Q-positive AMI was found in 100% of patients who belonged to the group of the 3rd tertile; recurrence of AMI occurred only in patients whose EMAR-II index was included in the 3rd tertile.

CONCLUSION: Conclusions: According to the results of endothelial function analysis with usу ща the marker of EMAP-II endothelial dysfunction in patients with AMI and concomitant type 2 DM, the increased level of this parameter was characteristic of pronounced violation of dilatation properties of the vascular wall and of the other indicators of complicated comorbid conditions.