We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Ambient monitoring of cyclophosphamide in manufacture and hospitals.
Cyclophosphamide (CP), one of the most commonly used cytostatic drugs, is known to be a human carcinogen. In this study, CP represents a model compound for the identification of potential exposure situations in the various phases of its manufacture and hospital use. Ambient air samples were taken in the various phases and analyzed for CP. A low detection limit (0.05 micrograms/m3 for a 1 m3 sample volume) was obtained for CP using the mass spectrometry method (MS) developed for this study. The detection limit was 1 microgram/m3 with the high performance liquid chromatography (HPLC) method. The correlation between the two methods was good. The highest potential exposure situations were found to occur during specific operations at the end of the process. During these operations the airborne CP concentrations may rise as high as several hundred micrograms/m3, and the workers must use supplied-air respirators, gloves and protective clothing. For the measurements in hospital use, air samples were taken from flow hoods. During normal working practices, no measurable amounts of CP could be observed. A filter from a flow hood, however, contained CP in measurable quantities, showing that occasional spilling may occur.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app