[The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones].

OBJECTIVE: To identify polymorphisms in the genes of dopaminergic and serotonergic systems associated with the risk of suicidal behavior in individuals with dependence on synthetic cathinones.

MATERIAL AND METHODS: One hundred and eighty-two men with the diagnosis of Substance dependence (ICD-10 F15) tested positive for metabolites of synthetic cathinones (a-PVP, MDPV) in the urine were studied. Genotyping was performed for rs1800497 DRD2 , rs4646984 DRD4 , VNTR 40 b.p. SLC6A3 , rs27072 SLC6A3 , rs6313 HTR2A and rs6296 HTR1B using PCR and RFLP technique.

RESULTS AND CONCLUSION: It was found that the genes of the serotonergic system HTR2A and HTR1B are predictors of the development of some endophenotypes of suicidal behavior in individuals with dependence on synthetic cathinones.