We have located links that may give you full text access.
Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial
[The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam].
Der Anaesthesist 1988 January
UNLABELLED: The benzodiazepine antagonist Ro 15-1788 has now been added to the series of antagonists which have been routinely used for a long time. In the present prospective, randomized double-blind study, it is investigated whether Ro 15-1788 is able to antagonize the effect of midazolam applied at a dosage of 0.2 mg/kg for induction of anesthesia.
PATIENTS, MATERIAL AND METHODS: Thirty female patients (age between 19 and 44 years) undergoing laparoscopy were included in the study. Premedication consisted of an oral dose of 2 mg flunitrazepam given on the evening before the intervention and a 7.5 mg oral dose of midazolam 45 min prior to the induction of anesthesia. After preoxygenation, midazolam was given intravenously at a dose of 0.2 mg/kg body weight for induction of anesthesia. Following extubation either Ro 15-1788 at a dosage of 0.2 mg (2 ml) or an adequate volume of placebo was given according to a randomized double-blind scheme. Those patients whose vigilance status did not change received either Ro 15-1788 or placebo every 60 s up to a maximum total dose of 10 ml. Prior to induction of anesthesia, 5 min after midazolam dosing, prior to and 5, 15, 30, 60 and 120 min after the application of Ro 15-1788, the following parameters were assessed using a multistep rating scale: degree of sedation, comprehension and collaboration, orientation in space and time, anterograde amnesia as well as blood pressure and heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
PATIENTS, MATERIAL AND METHODS: Thirty female patients (age between 19 and 44 years) undergoing laparoscopy were included in the study. Premedication consisted of an oral dose of 2 mg flunitrazepam given on the evening before the intervention and a 7.5 mg oral dose of midazolam 45 min prior to the induction of anesthesia. After preoxygenation, midazolam was given intravenously at a dose of 0.2 mg/kg body weight for induction of anesthesia. Following extubation either Ro 15-1788 at a dosage of 0.2 mg (2 ml) or an adequate volume of placebo was given according to a randomized double-blind scheme. Those patients whose vigilance status did not change received either Ro 15-1788 or placebo every 60 s up to a maximum total dose of 10 ml. Prior to induction of anesthesia, 5 min after midazolam dosing, prior to and 5, 15, 30, 60 and 120 min after the application of Ro 15-1788, the following parameters were assessed using a multistep rating scale: degree of sedation, comprehension and collaboration, orientation in space and time, anterograde amnesia as well as blood pressure and heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app