The Relaxant Mechanisms of Hydrogen Sulfide in Corpus Cavernosum.

In several animal and human studies, the contribution of the endothelium, nitric oxide/soluble guanosine monophosphate (NO/cGMP) pathway, adenylyl cyclase, phosphodiesterase (PDE), potassium (K+ ) channels, L-type calcium channels, Na+ -K+ -ATPase, muscarinic acetylcholine receptors, RhoA/Rho-kinase pathway, and cyclooxygenase (COX)/arachidonic acid cascade on the relaxant mechanism of L-cysteine/H2 S pathway in corpus cavernosum has been investigated. In this chapter the relaxant mechanisms of H2 S in corpus cavernosum is discussed with data available in the current relevant literature. Also, in vitro experimental procedure for mice corpus cavernosum which used to investigate the relaxant effect of H2 S is given in detail.