Glioblastoma Multiforme of the Conus Medullaris - Management Strategies and Complications.

Primary spinal glioblastoma multiforme (GBM) of the conus medullaris is a rare and devastating pathology. Presenting symptoms commonly include progressive neurologic deficits in the lower extremities, bowel and bladder dysfunction, and low back pain. Histologically, these tumors have high-grade features similar to their intracranial counterparts, however, recent advancements in the field of molecular oncology are beginning to elucidate a unique molecular blueprint for these spinal gliomas. Given the lack of standardized treatment strategies, we present our institutional experience in treating a small series of patients suffering from conus medullaris GBM and review the literature on relevant molecular markers, management strategies, and complication avoidance for this malignant pathology.