Incisional random skin biopsy, not punch biopsy, is an appropriate method for diagnosis of intravascular large B-cell lymphoma: A clinicopathological study of 25 patients.

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma characterised by atypical lymphoid cell proliferation within small vessels. We previously reported that random skin biopsy (RSB) is useful for the early diagnosis of IVLBCL; we emphasised the importance of subcutaneous fat tissue in biopsied specimens because most IVLBCL lesions are found in the vessels of subcutaneous fat tissue. However, Maekawa et al. found that seven of nine patients (78%) had IVLBCL lesions in the dermis. This article is protected by copyright. All rights reserved.